Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development

Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development

Succinylation represents an emerging class of post-translational modifications (PTMs), characterized by the enzymatic or non-enzymatic transfer of a negatively charged four-carbon succinyl group to the ϵ-amino group of lysine residues, mediated by succinyl-coenzyme A. Recent studies have highlighted...

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Bibliographic Details
Main Authors: Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
SIRT5
cancer
succinylation
desuccinylase
sirtuin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531246/full
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