Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancers
Purpose: Oral cancer patients with platinum-resistant disease and or early failures have limited treatment options. This analysis was planned to study the efficacy of metronomic chemotherapy in this group of patients. Materials and Methods: This was a retrospective analysis of oral cancer patients w...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2015-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=3;spage=161;epage=165;aulast=Patil |
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| author | Vijay M Patil Vanita Noronha Amit Joshi Rakesh Pinninti Sachin Dhumal Atanu Bhattacharjee Kumar Prabhash |
| author_facet | Vijay M Patil Vanita Noronha Amit Joshi Rakesh Pinninti Sachin Dhumal Atanu Bhattacharjee Kumar Prabhash |
| author_sort | Vijay M Patil |
| collection | DOAJ |
| description | Purpose: Oral cancer patients with platinum-resistant disease and or early failures have limited treatment options. This analysis was planned to study the efficacy of metronomic chemotherapy in this group of patients. Materials and Methods: This was a retrospective analysis of oral cancer patients who had squamous cell carcinoma and had an early failure and/or platinum-insensitive failure. Early failure was defined as a failure either within 1-month of adjuvant radiotherapy or within 6 months of chemoradiation (CTRT). A sample size of 100 patients was selected for this study. If ≥39 of 100 patients would have survived at 6 months with metronomic chemotherapy, then additional studies would be warranted. Results: The ECOG PS was 0-1 in 92 patients and 2 in 8 patients. The subsite of primary was buccal mucosa in 38 patients (38%), anterior two-third tongue (oral tongue) in 51 patients (51%), and alveolus in 11 patients (11%). The median estimated overall survival was 110 days (95% confidence interval [CI]: 85-134 days). The proportion of patients surviving at 6 months was 26.4% (95% CI: 17.9-35.6). Conclusion: Metronomic combination of methotrexate and celecoxib failed to meet its prespecified efficacy limit and should not be used in these patients as routine. |
| format | Article |
| id | doaj-art-ea0a909ad0f0499ca9c106f29456b51f |
| institution | DOAJ |
| issn | 0971-5851 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-ea0a909ad0f0499ca9c106f29456b51f2025-08-20T03:09:41ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512015-01-0136316116510.4103/0971-5851.166725Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancersVijay M PatilVanita NoronhaAmit JoshiRakesh PinnintiSachin DhumalAtanu BhattacharjeeKumar PrabhashPurpose: Oral cancer patients with platinum-resistant disease and or early failures have limited treatment options. This analysis was planned to study the efficacy of metronomic chemotherapy in this group of patients. Materials and Methods: This was a retrospective analysis of oral cancer patients who had squamous cell carcinoma and had an early failure and/or platinum-insensitive failure. Early failure was defined as a failure either within 1-month of adjuvant radiotherapy or within 6 months of chemoradiation (CTRT). A sample size of 100 patients was selected for this study. If ≥39 of 100 patients would have survived at 6 months with metronomic chemotherapy, then additional studies would be warranted. Results: The ECOG PS was 0-1 in 92 patients and 2 in 8 patients. The subsite of primary was buccal mucosa in 38 patients (38%), anterior two-third tongue (oral tongue) in 51 patients (51%), and alveolus in 11 patients (11%). The median estimated overall survival was 110 days (95% confidence interval [CI]: 85-134 days). The proportion of patients surviving at 6 months was 26.4% (95% CI: 17.9-35.6). Conclusion: Metronomic combination of methotrexate and celecoxib failed to meet its prespecified efficacy limit and should not be used in these patients as routine.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=3;spage=161;epage=165;aulast=PatilHead and neck cancermetronomicoral cancerpalliative chemotherapyplatinum-insensitiveplatinum refractoryplatinum-resistant |
| spellingShingle | Vijay M Patil Vanita Noronha Amit Joshi Rakesh Pinninti Sachin Dhumal Atanu Bhattacharjee Kumar Prabhash Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancers Indian Journal of Medical and Paediatric Oncology Head and neck cancer metronomic oral cancer palliative chemotherapy platinum-insensitive platinum refractory platinum-resistant |
| title | Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancers |
| title_full | Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancers |
| title_fullStr | Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancers |
| title_full_unstemmed | Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancers |
| title_short | Metronomic chemotherapy in platinum-insensitive failures and/or early failures postmultimodality management in oral cancers |
| title_sort | metronomic chemotherapy in platinum insensitive failures and or early failures postmultimodality management in oral cancers |
| topic | Head and neck cancer metronomic oral cancer palliative chemotherapy platinum-insensitive platinum refractory platinum-resistant |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=3;spage=161;epage=165;aulast=Patil |
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