OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles

OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles

ABSTRACT β-lactamases from Gram-negative bacteria are generally regarded as soluble, periplasmic enzymes. NDMs have been exceptionally characterized as lipoproteins anchored to the outer membrane. A bioinformatics study on all sequenced β-lactamases was performed that revealed a predominance of puta...

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Bibliographic Details
Main Authors:	Lucia Capodimonte, Fernando Teixeira Pinto Meireles, Guillermo Bahr, Robert A. Bonomo, Matteo Dal Peraro, Carolina López, Alejandro J. Vila
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-02-01
Series:	mBio
Subjects:	lipidated β-lactamases OXA β-lactamases Acinetobacter spp. outer membrane vesicles dissemination of antimicrobial resistance
Online Access:	https://journals.asm.org/doi/10.1128/mbio.03343-24
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