RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysis
Vitamin D is a lipid soluble steroid hormone, which plays a critical role in the calcium homeostasis, neuronal development, cellular differentiation, and growth by binding to vitamin D receptor (VDR). Associations between VDR gene polymorphism and Alzheimer’s disease (AD), Parkinson’s disease (PD),...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1377058/full |
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| author | Yanjun Du Peizhen Geng Qunqun Chen Laixi Han Lu Liu Maoquan Yang Mingzhu Tan Jun Meng Xiaojuan Sun Lidan Feng |
| author_facet | Yanjun Du Peizhen Geng Qunqun Chen Laixi Han Lu Liu Maoquan Yang Mingzhu Tan Jun Meng Xiaojuan Sun Lidan Feng |
| author_sort | Yanjun Du |
| collection | DOAJ |
| description | Vitamin D is a lipid soluble steroid hormone, which plays a critical role in the calcium homeostasis, neuronal development, cellular differentiation, and growth by binding to vitamin D receptor (VDR). Associations between VDR gene polymorphism and Alzheimer’s disease (AD), Parkinson’s disease (PD), and mild cognitive impairment (MCI) risk has been investigated extensively, but the results remain ambiguous. The aim of this study was to comprehensively assess the correlations between four VDR polymorphisms (FokI, BsmI, TaqI, and ApaI) and susceptibility to AD, PD, and MCI. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the relationship of interest. Pooled analyses suggested that the ApaI polymorphism decreased the overall AD risk, and the TaqI increased the overall PD susceptibility. In addition, the BsmI and ApaI polymorphisms were significantly correlated with the overall MCI risk. Stratified analysis by ethnicity further showed that the TaqI and ApaI genotypes reduced the AD predisposition among Caucasians, while the TaqI polymorphism enhanced the PD risk among Asians. Intriguingly, carriers with the BB genotype significantly decreased the MCI risk in Asian descents, and the ApaI variant elevated the predisposition to MCI in Caucasians and Asians. Further studies are need to identify the role of VDR polymorphisms in AD, PD, and MCI susceptibility. |
| format | Article |
| id | doaj-art-e9ef105ccfde4137b1a2bb894b5fbc8a |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-e9ef105ccfde4137b1a2bb894b5fbc8a2025-01-13T13:49:51ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-04-011610.3389/fnagi.2024.13770581377058RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysisYanjun Du0Peizhen Geng1Qunqun Chen2Laixi Han3Lu Liu4Maoquan Yang5Mingzhu Tan6Jun Meng7Xiaojuan Sun8Lidan Feng9Department of Encephalopathy, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Rehabilitation, Weifang Brain Hospital, Weifang, Shandong, ChinaDepartment of Rehabilitation, Weifang Brain Hospital, Weifang, Shandong, ChinaDepartment of Occupational Diseases, Weifang People’s Hospital, Weifang, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Occupational Diseases, Weifang People’s Hospital, Weifang, Shandong, ChinaDepartment of Occupational Diseases, Weifang People’s Hospital, Weifang, Shandong, ChinaDepartment of Occupational Diseases, Weifang People’s Hospital, Weifang, Shandong, ChinaDepartment of Rehabilitation, Weifang People’s Hospital, Weifang, Shandong, ChinaVitamin D is a lipid soluble steroid hormone, which plays a critical role in the calcium homeostasis, neuronal development, cellular differentiation, and growth by binding to vitamin D receptor (VDR). Associations between VDR gene polymorphism and Alzheimer’s disease (AD), Parkinson’s disease (PD), and mild cognitive impairment (MCI) risk has been investigated extensively, but the results remain ambiguous. The aim of this study was to comprehensively assess the correlations between four VDR polymorphisms (FokI, BsmI, TaqI, and ApaI) and susceptibility to AD, PD, and MCI. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the relationship of interest. Pooled analyses suggested that the ApaI polymorphism decreased the overall AD risk, and the TaqI increased the overall PD susceptibility. In addition, the BsmI and ApaI polymorphisms were significantly correlated with the overall MCI risk. Stratified analysis by ethnicity further showed that the TaqI and ApaI genotypes reduced the AD predisposition among Caucasians, while the TaqI polymorphism enhanced the PD risk among Asians. Intriguingly, carriers with the BB genotype significantly decreased the MCI risk in Asian descents, and the ApaI variant elevated the predisposition to MCI in Caucasians and Asians. Further studies are need to identify the role of VDR polymorphisms in AD, PD, and MCI susceptibility.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1377058/fullAlzheimer’s diseaseParkinson’s diseasemild cognitive impairmentVDRgene polymorphismsusceptibility |
| spellingShingle | Yanjun Du Peizhen Geng Qunqun Chen Laixi Han Lu Liu Maoquan Yang Mingzhu Tan Jun Meng Xiaojuan Sun Lidan Feng RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysis Frontiers in Aging Neuroscience Alzheimer’s disease Parkinson’s disease mild cognitive impairment VDR gene polymorphism susceptibility |
| title | RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysis |
| title_full | RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysis |
| title_fullStr | RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysis |
| title_full_unstemmed | RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysis |
| title_short | RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analysis |
| title_sort | retracted associations of vitamin d receptor polymorphisms with risk of alzheimer s disease parkinson s disease and mild cognitive impairment a systematic review and meta analysis |
| topic | Alzheimer’s disease Parkinson’s disease mild cognitive impairment VDR gene polymorphism susceptibility |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1377058/full |
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