Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli
The increase in bacterial antibiotic resistance poses a significant threat to the effectiveness of antibiotics, and there is growing evidence suggesting that global warming may speed up this process. However, the direct influence of temperature on the development of antibiotic resistance and the und...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Environmental Science and Ecotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666498424000899 |
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| _version_ | 1846166936416681984 |
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| author | Wenya Zhao Shikan Zheng Chengsong Ye Jianguo Li Xin Yu |
| author_facet | Wenya Zhao Shikan Zheng Chengsong Ye Jianguo Li Xin Yu |
| author_sort | Wenya Zhao |
| collection | DOAJ |
| description | The increase in bacterial antibiotic resistance poses a significant threat to the effectiveness of antibiotics, and there is growing evidence suggesting that global warming may speed up this process. However, the direct influence of temperature on the development of antibiotic resistance and the underlying mechanisms is not yet fully understood. Here we show that antibiotic resistance exhibits a nonlinear response to elevated temperatures under the combined stress of temperatures and antibiotics. We find that the effectiveness of gatifloxacin against Escherichia coli significantly diminishes at 42 °C, while resistance increases 256-fold at 27 °C. Additionally, the increased transcription levels of genes such as marA, ygfA, and ibpB with rising temperatures, along with gene mutations at different sites, explain the observed variability in resistance patterns. These findings highlight the complexity of antibiotic resistance evolution and the urgent need for comprehensive studies to understand and mitigate the effects of global warming on antibiotic resistance. |
| format | Article |
| id | doaj-art-e9d623e15dec4ff0b4a7e10e464a93a6 |
| institution | Kabale University |
| issn | 2666-4984 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environmental Science and Ecotechnology |
| spelling | doaj-art-e9d623e15dec4ff0b4a7e10e464a93a62024-11-15T06:15:17ZengElsevierEnvironmental Science and Ecotechnology2666-49842024-11-0122100475Nonlinear impacts of temperature on antibiotic resistance in Escherichia coliWenya Zhao0Shikan Zheng1Chengsong Ye2Jianguo Li3Xin Yu4College of the Environment and Ecology, Xiamen University, Xiamen, 361102, China; Fujian Key Laboratory of Coastal Pollution Prevention and Control, Xiamen, 361102, ChinaCollege of the Environment and Ecology, Xiamen University, Xiamen, 361102, China; Fujian Key Laboratory of Coastal Pollution Prevention and Control, Xiamen, 361102, ChinaCollege of the Environment and Ecology, Xiamen University, Xiamen, 361102, China; Fujian Key Laboratory of Coastal Pollution Prevention and Control, Xiamen, 361102, ChinaCollege of the Environment and Ecology, Xiamen University, Xiamen, 361102, China; Fujian Key Laboratory of Coastal Pollution Prevention and Control, Xiamen, 361102, ChinaCollege of the Environment and Ecology, Xiamen University, Xiamen, 361102, China; Fujian Key Laboratory of Coastal Pollution Prevention and Control, Xiamen, 361102, China; Corresponding author. College of the Environment and Ecology, Xiamen University, Xiamen,361102, China.The increase in bacterial antibiotic resistance poses a significant threat to the effectiveness of antibiotics, and there is growing evidence suggesting that global warming may speed up this process. However, the direct influence of temperature on the development of antibiotic resistance and the underlying mechanisms is not yet fully understood. Here we show that antibiotic resistance exhibits a nonlinear response to elevated temperatures under the combined stress of temperatures and antibiotics. We find that the effectiveness of gatifloxacin against Escherichia coli significantly diminishes at 42 °C, while resistance increases 256-fold at 27 °C. Additionally, the increased transcription levels of genes such as marA, ygfA, and ibpB with rising temperatures, along with gene mutations at different sites, explain the observed variability in resistance patterns. These findings highlight the complexity of antibiotic resistance evolution and the urgent need for comprehensive studies to understand and mitigate the effects of global warming on antibiotic resistance.http://www.sciencedirect.com/science/article/pii/S2666498424000899Antibiotic resistanceTemperatureGatifloxacinResistance evolutionFitness costs |
| spellingShingle | Wenya Zhao Shikan Zheng Chengsong Ye Jianguo Li Xin Yu Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli Environmental Science and Ecotechnology Antibiotic resistance Temperature Gatifloxacin Resistance evolution Fitness costs |
| title | Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli |
| title_full | Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli |
| title_fullStr | Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli |
| title_full_unstemmed | Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli |
| title_short | Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli |
| title_sort | nonlinear impacts of temperature on antibiotic resistance in escherichia coli |
| topic | Antibiotic resistance Temperature Gatifloxacin Resistance evolution Fitness costs |
| url | http://www.sciencedirect.com/science/article/pii/S2666498424000899 |
| work_keys_str_mv | AT wenyazhao nonlinearimpactsoftemperatureonantibioticresistanceinescherichiacoli AT shikanzheng nonlinearimpactsoftemperatureonantibioticresistanceinescherichiacoli AT chengsongye nonlinearimpactsoftemperatureonantibioticresistanceinescherichiacoli AT jianguoli nonlinearimpactsoftemperatureonantibioticresistanceinescherichiacoli AT xinyu nonlinearimpactsoftemperatureonantibioticresistanceinescherichiacoli |