Multimodal management and complete resection of invasive Type B3 thymoma with vascular reconstruction: a case report
Abstract Introduction Thymomas and thymic carcinomas are rare anterior mediastinal tumours, accounting for 0.2–1.5% of all cancers. Surgical resection is key to treatment, though invasion of surrounding structures like great vessels can complicate this. This case report details the management of a t...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-024-03318-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544325685575680 |
|---|---|
| author | Puiyee Sophia Chan Akshay J. Patel Gianluca Lucchese Andrea Bille |
| author_facet | Puiyee Sophia Chan Akshay J. Patel Gianluca Lucchese Andrea Bille |
| author_sort | Puiyee Sophia Chan |
| collection | DOAJ |
| description | Abstract Introduction Thymomas and thymic carcinomas are rare anterior mediastinal tumours, accounting for 0.2–1.5% of all cancers. Surgical resection is key to treatment, though invasion of surrounding structures like great vessels can complicate this. This case report details the management of a type B3 thymoma (T4 N0 M0) in a 41-year-old male. Case report A 41-year-old male presented with myasthenic symptoms and was diagnosed with a large thymic mass involving the brachiocephalic vein and superior vena cava. After 4 cycles of neoadjuvant chemotherapy, partial resection was performed, followed by radiotherapy. Residual disease led to a second surgery, during which tumour resection and vascular reconstruction using cardiopulmonary bypass were successfully completed. Postoperative recovery was uneventful. Discussion Complete resection, including re-resection, when necessary, is crucial for improved outcomes in thymoma patients. Even with great vessel invasion, aggressive surgery, coupled with chemotherapy and vascular reconstruction, can achieve good survival outcomes. Conclusion Multimodal management, including chemotherapy, complete resection, and vascular reconstruction, offers the best prognosis for invasive thymomas, even with great vessel involvement. |
| format | Article |
| id | doaj-art-e9d58ba7e54c413c9f68e4bbb26f0fa3 |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-e9d58ba7e54c413c9f68e4bbb26f0fa32025-01-12T12:38:50ZengBMCJournal of Cardiothoracic Surgery1749-80902025-01-012011510.1186/s13019-024-03318-1Multimodal management and complete resection of invasive Type B3 thymoma with vascular reconstruction: a case reportPuiyee Sophia Chan0Akshay J. Patel1Gianluca Lucchese2Andrea Bille3Department of Thoracic Surgery, Guy’s and St Thomas’ NHS Foundation TrustDepartment of Thoracic Surgery, Guy’s and St Thomas’ NHS Foundation TrustDepartment of Cardiac Surgery, Guy’s and St Thomas’ NHS Foundation TrustDepartment of Thoracic Surgery, Guy’s and St Thomas’ NHS Foundation TrustAbstract Introduction Thymomas and thymic carcinomas are rare anterior mediastinal tumours, accounting for 0.2–1.5% of all cancers. Surgical resection is key to treatment, though invasion of surrounding structures like great vessels can complicate this. This case report details the management of a type B3 thymoma (T4 N0 M0) in a 41-year-old male. Case report A 41-year-old male presented with myasthenic symptoms and was diagnosed with a large thymic mass involving the brachiocephalic vein and superior vena cava. After 4 cycles of neoadjuvant chemotherapy, partial resection was performed, followed by radiotherapy. Residual disease led to a second surgery, during which tumour resection and vascular reconstruction using cardiopulmonary bypass were successfully completed. Postoperative recovery was uneventful. Discussion Complete resection, including re-resection, when necessary, is crucial for improved outcomes in thymoma patients. Even with great vessel invasion, aggressive surgery, coupled with chemotherapy and vascular reconstruction, can achieve good survival outcomes. Conclusion Multimodal management, including chemotherapy, complete resection, and vascular reconstruction, offers the best prognosis for invasive thymomas, even with great vessel involvement.https://doi.org/10.1186/s13019-024-03318-1Thymic epithelial tumours (TET)ThymomaChemoradiationNeoadjuvantRedo surgery |
| spellingShingle | Puiyee Sophia Chan Akshay J. Patel Gianluca Lucchese Andrea Bille Multimodal management and complete resection of invasive Type B3 thymoma with vascular reconstruction: a case report Journal of Cardiothoracic Surgery Thymic epithelial tumours (TET) Thymoma Chemoradiation Neoadjuvant Redo surgery |
| title | Multimodal management and complete resection of invasive Type B3 thymoma with vascular reconstruction: a case report |
| title_full | Multimodal management and complete resection of invasive Type B3 thymoma with vascular reconstruction: a case report |
| title_fullStr | Multimodal management and complete resection of invasive Type B3 thymoma with vascular reconstruction: a case report |
| title_full_unstemmed | Multimodal management and complete resection of invasive Type B3 thymoma with vascular reconstruction: a case report |
| title_short | Multimodal management and complete resection of invasive Type B3 thymoma with vascular reconstruction: a case report |
| title_sort | multimodal management and complete resection of invasive type b3 thymoma with vascular reconstruction a case report |
| topic | Thymic epithelial tumours (TET) Thymoma Chemoradiation Neoadjuvant Redo surgery |
| url | https://doi.org/10.1186/s13019-024-03318-1 |
| work_keys_str_mv | AT puiyeesophiachan multimodalmanagementandcompleteresectionofinvasivetypeb3thymomawithvascularreconstructionacasereport AT akshayjpatel multimodalmanagementandcompleteresectionofinvasivetypeb3thymomawithvascularreconstructionacasereport AT gianlucalucchese multimodalmanagementandcompleteresectionofinvasivetypeb3thymomawithvascularreconstructionacasereport AT andreabille multimodalmanagementandcompleteresectionofinvasivetypeb3thymomawithvascularreconstructionacasereport |