Intraoperative risk of bleeding and its prevention during transcervical myomectomy
In this study clinical, functional and morphological assessment of the effectiveness of synthetic analogue of vasopressin (terlipressin) has been made. The aim of the study was to assess study drug prevention efficasy of excessive bleeding during hysteroscopic myomectomy in patients with submucosal...
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| Format: | Article |
| Language: | English |
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Dnipro State Medical University
2014-09-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://medpers.dsma.dp.ua/issues/2014/N3/44-51.pdf |
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| author | Kaminsky V.V. Dunaevska V.V. Medvediev M.V. |
| author_facet | Kaminsky V.V. Dunaevska V.V. Medvediev M.V. |
| author_sort | Kaminsky V.V. |
| collection | DOAJ |
| description | In this study clinical, functional and morphological assessment of the effectiveness of synthetic analogue of vasopressin (terlipressin) has been made. The aim of the study was to assess study drug prevention efficasy of excessive bleeding during hysteroscopic myomectomy in patients with submucosal uterine leiomyoma. In 19 women with uterine leiomyoma 15 minutes prior to surgery terlipressin was administered in para¬cervical route in the dosage 0.6 mg in 10 ml of normal saline. In the comparison group, which was also consisted of 19 women in the presence of significant blood loss during myoma resection intravenous oxytocin was used. The use of terlipressin helped to reduce the volume of blood loss during surgery almost by 2 times, reduced the duration of surgery and the risk of postoperative complications. On the basis of the ultrasonic doppler blood flow studies in uterine vessels, morphological and immunohistochemical studies of hemocapillars density in removed myoma nodules it was found that terlipressin contributes significantly to reduction of the number of functioning blood vessels and also to reduction of blood flow in all parts of the vascular system both in uterus and in leiomyoma, whereas oxytocin was not observed to decrease myometrium perfusion. It conclusion the study results showed that terlipressin use is the most effective method of prevention of excessive blood loss during hysteroscopic myoma resection. |
| format | Article |
| id | doaj-art-e9d3485adb7847b9bfcce9b3392236a5 |
| institution | Kabale University |
| issn | 2307-0404 2307-0404 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-e9d3485adb7847b9bfcce9b3392236a52025-01-02T01:25:45ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042014-09-011934451Intraoperative risk of bleeding and its prevention during transcervical myomectomyKaminsky V.V.0Dunaevska V.V.1Medvediev M.V. 2Shupyk National medical academy of postgraduate educationShupyk National medical academy of postgraduate educationSE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»In this study clinical, functional and morphological assessment of the effectiveness of synthetic analogue of vasopressin (terlipressin) has been made. The aim of the study was to assess study drug prevention efficasy of excessive bleeding during hysteroscopic myomectomy in patients with submucosal uterine leiomyoma. In 19 women with uterine leiomyoma 15 minutes prior to surgery terlipressin was administered in para¬cervical route in the dosage 0.6 mg in 10 ml of normal saline. In the comparison group, which was also consisted of 19 women in the presence of significant blood loss during myoma resection intravenous oxytocin was used. The use of terlipressin helped to reduce the volume of blood loss during surgery almost by 2 times, reduced the duration of surgery and the risk of postoperative complications. On the basis of the ultrasonic doppler blood flow studies in uterine vessels, morphological and immunohistochemical studies of hemocapillars density in removed myoma nodules it was found that terlipressin contributes significantly to reduction of the number of functioning blood vessels and also to reduction of blood flow in all parts of the vascular system both in uterus and in leiomyoma, whereas oxytocin was not observed to decrease myometrium perfusion. It conclusion the study results showed that terlipressin use is the most effective method of prevention of excessive blood loss during hysteroscopic myoma resection.http://medpers.dsma.dp.ua/issues/2014/N3/44-51.pdfuterine leiomyomaterlipressinblood losshysteroscopy |
| spellingShingle | Kaminsky V.V. Dunaevska V.V. Medvediev M.V. Intraoperative risk of bleeding and its prevention during transcervical myomectomy Medičnì Perspektivi uterine leiomyoma terlipressin blood loss hysteroscopy |
| title | Intraoperative risk of bleeding and its prevention during transcervical myomectomy |
| title_full | Intraoperative risk of bleeding and its prevention during transcervical myomectomy |
| title_fullStr | Intraoperative risk of bleeding and its prevention during transcervical myomectomy |
| title_full_unstemmed | Intraoperative risk of bleeding and its prevention during transcervical myomectomy |
| title_short | Intraoperative risk of bleeding and its prevention during transcervical myomectomy |
| title_sort | intraoperative risk of bleeding and its prevention during transcervical myomectomy |
| topic | uterine leiomyoma terlipressin blood loss hysteroscopy |
| url | http://medpers.dsma.dp.ua/issues/2014/N3/44-51.pdf |
| work_keys_str_mv | AT kaminskyvv intraoperativeriskofbleedinganditspreventionduringtranscervicalmyomectomy AT dunaevskavv intraoperativeriskofbleedinganditspreventionduringtranscervicalmyomectomy AT medvedievmv intraoperativeriskofbleedinganditspreventionduringtranscervicalmyomectomy |