The dynamics of thrombolysis over time in acute immunologic reactions
Abstract Allergic reactions and angioedema are important immunologic conditions in acute care settings. Prior data indicate an association between symptom severity and maximum lysis (ML) in thromboelastometry. We aimed to evaluate the dynamics of ML two hours after admission to the emergency departm...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-84070-3 |
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| author | Calvin Lukas Kienbacher Christian Schörgenhofer Gerhard Ruzicka Jürgen Grafeneder Christine Hufnagl Bernd Jilma Michael Schwameis Harald Herkner |
| author_facet | Calvin Lukas Kienbacher Christian Schörgenhofer Gerhard Ruzicka Jürgen Grafeneder Christine Hufnagl Bernd Jilma Michael Schwameis Harald Herkner |
| author_sort | Calvin Lukas Kienbacher |
| collection | DOAJ |
| description | Abstract Allergic reactions and angioedema are important immunologic conditions in acute care settings. Prior data indicate an association between symptom severity and maximum lysis (ML) in thromboelastometry. We aimed to evaluate the dynamics of ML two hours after admission to the emergency department. We determined ML with thromboelastometry using extrinsic testing (EXTEM, ROTEM®, Werfen GmbH, Munich, Germany) at the presentation of patients with immunologic reactions and approximately two hours thereafter (after the observation interval). The median test was used to compare the extent of ML between individuals who were still symptomatic after the observation interval and those who were asymptomatic. We prospectively enrolled 16 individuals (10 (63%) female, mean age 50 ± 14 years). Of these, 6 (38%) were still symptomatic after the observation interval. These patients at that time had significantly higher ML than those who were asymptomatic (14% (IQR 12–17) vs. 8% (IQR 4–10), p = 0.002). To conclude, in emergency department patients with immunologic reactions, symptoms after 2 h of observation may be associated with alterations in ML. |
| format | Article |
| id | doaj-art-e9c47932878b4efba411e60918fb8232 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e9c47932878b4efba411e60918fb82322025-01-05T12:17:31ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-84070-3The dynamics of thrombolysis over time in acute immunologic reactionsCalvin Lukas Kienbacher0Christian Schörgenhofer1Gerhard Ruzicka2Jürgen Grafeneder3Christine Hufnagl4Bernd Jilma5Michael Schwameis6Harald Herkner7Department of Emergency Medicine, Medical University of ViennaDepartment of Clinical Pharmacology, Medical University of ViennaDepartment of Emergency Medicine, Medical University of ViennaDepartment of Emergency Medicine, Medical University of ViennaDepartment of Emergency Medicine, Medical University of ViennaDepartment of Clinical Pharmacology, Medical University of ViennaDepartment of Emergency Medicine, Medical University of ViennaDepartment of Emergency Medicine, Medical University of ViennaAbstract Allergic reactions and angioedema are important immunologic conditions in acute care settings. Prior data indicate an association between symptom severity and maximum lysis (ML) in thromboelastometry. We aimed to evaluate the dynamics of ML two hours after admission to the emergency department. We determined ML with thromboelastometry using extrinsic testing (EXTEM, ROTEM®, Werfen GmbH, Munich, Germany) at the presentation of patients with immunologic reactions and approximately two hours thereafter (after the observation interval). The median test was used to compare the extent of ML between individuals who were still symptomatic after the observation interval and those who were asymptomatic. We prospectively enrolled 16 individuals (10 (63%) female, mean age 50 ± 14 years). Of these, 6 (38%) were still symptomatic after the observation interval. These patients at that time had significantly higher ML than those who were asymptomatic (14% (IQR 12–17) vs. 8% (IQR 4–10), p = 0.002). To conclude, in emergency department patients with immunologic reactions, symptoms after 2 h of observation may be associated with alterations in ML.https://doi.org/10.1038/s41598-024-84070-3 |
| spellingShingle | Calvin Lukas Kienbacher Christian Schörgenhofer Gerhard Ruzicka Jürgen Grafeneder Christine Hufnagl Bernd Jilma Michael Schwameis Harald Herkner The dynamics of thrombolysis over time in acute immunologic reactions Scientific Reports |
| title | The dynamics of thrombolysis over time in acute immunologic reactions |
| title_full | The dynamics of thrombolysis over time in acute immunologic reactions |
| title_fullStr | The dynamics of thrombolysis over time in acute immunologic reactions |
| title_full_unstemmed | The dynamics of thrombolysis over time in acute immunologic reactions |
| title_short | The dynamics of thrombolysis over time in acute immunologic reactions |
| title_sort | dynamics of thrombolysis over time in acute immunologic reactions |
| url | https://doi.org/10.1038/s41598-024-84070-3 |
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