Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental study
Introduction: Despite the relatively low prevalence of metastatic cervical spinal tumor, these entities give rise to more profound complications than thoracic and lumbar spinal tumor. However, it is regrettable that experimental investigation has thus far shown a dearth of attention to metastatic ce...
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| Format: | Article |
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Elsevier
2024-01-01
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| Series: | Brain and Spine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772529424000985 |
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| author | Shunsuke Sato Masahito Takahashi Kazuhiko Satomi Hideaki Ohne Takumi Takeuchi Atsushi Hasegawa Shoichi Ichimura Naobumi Hosogane |
| author_facet | Shunsuke Sato Masahito Takahashi Kazuhiko Satomi Hideaki Ohne Takumi Takeuchi Atsushi Hasegawa Shoichi Ichimura Naobumi Hosogane |
| author_sort | Shunsuke Sato |
| collection | DOAJ |
| description | Introduction: Despite the relatively low prevalence of metastatic cervical spinal tumor, these entities give rise to more profound complications than thoracic and lumbar spinal tumor. However, it is regrettable that experimental investigation has thus far shown a dearth of attention to metastatic cervical spinal tumor. Research question: What is the conceptualization and realization of quadriparesis resulting from metastatic cervical spinal tumor? Material and methods: Using Fischer 344 rats as the experimental cohort, this study orchestrated the engraftment of tumor cells procured from the 13762 MAT B III cell line (RRID: CVCL_3475), which represents mammary adenocarcinoma. These cells were engrafted into the vertebrae of the cervical spine. A comprehensive inquiry encompassing behavioral assessments, histological evaluations, and microangiographic analyses conducted after the aforementioned cellular transplantation was subsequently pursued. Results: The incidence of cervical paralysis was 61.1%. Notably, the evolution of paralysis was unfurled by two distinctive temporal phases within its natural history. A meticulous histological examination facilitated delineation of the tumor's posterior expansion within the spinal canal. Simultaneously, the tumor exhibited anterior and lateral encroachment on the spinal cord, inducing compression from all sides. Augmented by microangiographic investigations, conspicuous attenuation of stained blood vessels within the affected anterior horn and funiculus of the spinal cord was observed. Discussion and conclusion: The pathological advancement of paralysis stemming from metastatic cervical spinal tumor is now apprehended to unfurl through a biphasic phase. The initial phase is characterized by gradual unfurling spanning several days, juxtaposed against the second phase marked by swift and accelerated progression. |
| format | Article |
| id | doaj-art-e9a277a1aa6a46b483fefcfa48e8d341 |
| institution | Kabale University |
| issn | 2772-5294 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain and Spine |
| spelling | doaj-art-e9a277a1aa6a46b483fefcfa48e8d3412024-12-15T06:18:30ZengElsevierBrain and Spine2772-52942024-01-014102842Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental studyShunsuke Sato0Masahito Takahashi1Kazuhiko Satomi2Hideaki Ohne3Takumi Takeuchi4Atsushi Hasegawa5Shoichi Ichimura6Naobumi Hosogane7Department of Orthopaedic Surgery, Kyorin University, Tokyo, JapanDepartment of Orthopaedic Surgery, Kyorin University, Tokyo, Japan; Corresponding author. Department of Orthopaedic Surgery, Kyorin University, 6-20-2 Shinkawa, Mitaka City, Tokyo, 181-8611, Japan.Orthopaedic Surgery, Mitaka Hospital, Tokyo, JapanDepartment of Orthopaedic Surgery, Kyorin University, Tokyo, JapanDepartment of Orthopaedic Surgery, Kyorin University, Tokyo, JapanDepartment of Orthopaedic Surgery, Kyorin University, Tokyo, JapanOrthopaedic Surgery, Kyorin University Suginami Hospital, Tokyo, JapanDepartment of Orthopaedic Surgery, Kyorin University, Tokyo, JapanIntroduction: Despite the relatively low prevalence of metastatic cervical spinal tumor, these entities give rise to more profound complications than thoracic and lumbar spinal tumor. However, it is regrettable that experimental investigation has thus far shown a dearth of attention to metastatic cervical spinal tumor. Research question: What is the conceptualization and realization of quadriparesis resulting from metastatic cervical spinal tumor? Material and methods: Using Fischer 344 rats as the experimental cohort, this study orchestrated the engraftment of tumor cells procured from the 13762 MAT B III cell line (RRID: CVCL_3475), which represents mammary adenocarcinoma. These cells were engrafted into the vertebrae of the cervical spine. A comprehensive inquiry encompassing behavioral assessments, histological evaluations, and microangiographic analyses conducted after the aforementioned cellular transplantation was subsequently pursued. Results: The incidence of cervical paralysis was 61.1%. Notably, the evolution of paralysis was unfurled by two distinctive temporal phases within its natural history. A meticulous histological examination facilitated delineation of the tumor's posterior expansion within the spinal canal. Simultaneously, the tumor exhibited anterior and lateral encroachment on the spinal cord, inducing compression from all sides. Augmented by microangiographic investigations, conspicuous attenuation of stained blood vessels within the affected anterior horn and funiculus of the spinal cord was observed. Discussion and conclusion: The pathological advancement of paralysis stemming from metastatic cervical spinal tumor is now apprehended to unfurl through a biphasic phase. The initial phase is characterized by gradual unfurling spanning several days, juxtaposed against the second phase marked by swift and accelerated progression.http://www.sciencedirect.com/science/article/pii/S2772529424000985Cervical spineExperimental studyMetastatic spinal tumorParalysisEpidural tumor |
| spellingShingle | Shunsuke Sato Masahito Takahashi Kazuhiko Satomi Hideaki Ohne Takumi Takeuchi Atsushi Hasegawa Shoichi Ichimura Naobumi Hosogane Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental study Brain and Spine Cervical spine Experimental study Metastatic spinal tumor Paralysis Epidural tumor |
| title | Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental study |
| title_full | Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental study |
| title_fullStr | Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental study |
| title_full_unstemmed | Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental study |
| title_short | Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental study |
| title_sort | unveiling the natural history of paralysis in metastatic cervical spinal tumor an experimental study |
| topic | Cervical spine Experimental study Metastatic spinal tumor Paralysis Epidural tumor |
| url | http://www.sciencedirect.com/science/article/pii/S2772529424000985 |
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