Benefit of Avasopasem Manganese on Severe Oral Mucositis in Head and Neck Cancer in the ROMAN Trial: Unplanned Secondary Analysis

Benefit of Avasopasem Manganese on Severe Oral Mucositis in Head and Neck Cancer in the ROMAN Trial: Unplanned Secondary Analysis

Purpose: Oral mucositis (OM) is a debilitating side effect of cisplatin and intensity-modulated radiation therapy (IMRT) in patients with head and neck cancer. The phase 3 ROMAN trial showed avasopasem manganese (AVA) significantly decreased individual endpoints of incidence and duration of severe o...

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Main Authors: Carryn Anderson, MD, Samuel Salvaggio, PhD, Mickaël De Backer, PhD, Jean-Christophe Chiem, PhD, Gary Walker, MD, MPH, MS, Deborah Saunders, DMD, BSc, Christopher M. Lee, MD, Neal Dunlap, MD, Eugene Kennedy, MD, Robert Beardsley, PhD, Benton Schoen, BA, Marc Buyse, ScD
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Advances in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2452109424002379
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