Primary cardiac lymphoma: a clinicopathological study of 121 cases
BackgroundPrimary cardiac lymphoma (PCL) is an exceedingly uncommon type of lymphoma that primarily affects the heart and/or pericardium, or manifests through cardiac symptoms due to myocardial infiltration. The infrequency of PCL, coupled with its non-specific clinical presentations, often complica...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1509100/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556903220477952 |
|---|---|
| author | Shuhui Zhuang Liudi Chang Liudi Chang Xiaoxi Feng Xiaoxi Feng Weiwen Hu Weiwen Hu Zhaobo Yang Yuanyuan Zhang |
| author_facet | Shuhui Zhuang Liudi Chang Liudi Chang Xiaoxi Feng Xiaoxi Feng Weiwen Hu Weiwen Hu Zhaobo Yang Yuanyuan Zhang |
| author_sort | Shuhui Zhuang |
| collection | DOAJ |
| description | BackgroundPrimary cardiac lymphoma (PCL) is an exceedingly uncommon type of lymphoma that primarily affects the heart and/or pericardium, or manifests through cardiac symptoms due to myocardial infiltration. The infrequency of PCL, coupled with its non-specific clinical presentations, often complicates early diagnosis. This study aims to fill the existing gap in clinical knowledge regarding PCL by detailing a case of PCL and examining its clinical features, auxiliary examinations, treatment approaches, and prognostic outcomes, thereby facilitating early detection and enhancing patient care.MethodsA thorough search of the PubMed and Chinese National Knowledge Infrastructure (CNKI) database was performed using keywords “heart” and “lymphoma” or “primary cardiac lymphoma”. This search encompassed publications from January 1, 2014, to November 1, 2024.ResultsThe review included 121 cases. These cases usually present with atypical symptoms, mainly circulatory and respiratory, including chest tightness, dyspnea, and edema, along with occasional neurological and gastrointestinal symptoms. Echocardiography served as the primary diagnostic method in 92.6% of cases, while a definitive diagnosis was achieved through pathological examination in all cases (100%). Treatment strategies predominantly included surgical intervention (44.6%) and chemotherapy (76.0%). Although surgery did not have a significant effect on survival rates, chemotherapy proved to be critical in improving patient survival.ConclusionsPCL, which arises in the cardiac or pericardial areas, is generally associated with a poor prognosis. It is essential for clinicians to develop a greater awareness and understanding of the characteristics of PCL to enhance early diagnosis. The timely initiation of chemotherapy is vital for improving survival rates and the overall quality of life for patients with PCL. |
| format | Article |
| id | doaj-art-e986ec327c994f86b500e85186ffdebf |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-e986ec327c994f86b500e85186ffdebf2025-01-07T05:23:50ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15091001509100Primary cardiac lymphoma: a clinicopathological study of 121 casesShuhui Zhuang0Liudi Chang1Liudi Chang2Xiaoxi Feng3Xiaoxi Feng4Weiwen Hu5Weiwen Hu6Zhaobo Yang7Yuanyuan Zhang8Department of Hematology, Linyi People’s Hospital, Linyi, Shandong, ChinaDepartment of Hematology, Linyi People’s Hospital, Linyi, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Hematology, Linyi People’s Hospital, Linyi, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Hematology, Linyi People’s Hospital, Linyi, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaSpine surgery, Linyi People’s Hospital, Shandong University, Linyi, Shandong, ChinaDepartment of Hematology, Linyi People’s Hospital, Linyi, Shandong, ChinaBackgroundPrimary cardiac lymphoma (PCL) is an exceedingly uncommon type of lymphoma that primarily affects the heart and/or pericardium, or manifests through cardiac symptoms due to myocardial infiltration. The infrequency of PCL, coupled with its non-specific clinical presentations, often complicates early diagnosis. This study aims to fill the existing gap in clinical knowledge regarding PCL by detailing a case of PCL and examining its clinical features, auxiliary examinations, treatment approaches, and prognostic outcomes, thereby facilitating early detection and enhancing patient care.MethodsA thorough search of the PubMed and Chinese National Knowledge Infrastructure (CNKI) database was performed using keywords “heart” and “lymphoma” or “primary cardiac lymphoma”. This search encompassed publications from January 1, 2014, to November 1, 2024.ResultsThe review included 121 cases. These cases usually present with atypical symptoms, mainly circulatory and respiratory, including chest tightness, dyspnea, and edema, along with occasional neurological and gastrointestinal symptoms. Echocardiography served as the primary diagnostic method in 92.6% of cases, while a definitive diagnosis was achieved through pathological examination in all cases (100%). Treatment strategies predominantly included surgical intervention (44.6%) and chemotherapy (76.0%). Although surgery did not have a significant effect on survival rates, chemotherapy proved to be critical in improving patient survival.ConclusionsPCL, which arises in the cardiac or pericardial areas, is generally associated with a poor prognosis. It is essential for clinicians to develop a greater awareness and understanding of the characteristics of PCL to enhance early diagnosis. The timely initiation of chemotherapy is vital for improving survival rates and the overall quality of life for patients with PCL.https://www.frontiersin.org/articles/10.3389/fonc.2024.1509100/fullprimary cardiac lymphomadiffuse large B-cell lymphomadiagnosistreatmentprognosis |
| spellingShingle | Shuhui Zhuang Liudi Chang Liudi Chang Xiaoxi Feng Xiaoxi Feng Weiwen Hu Weiwen Hu Zhaobo Yang Yuanyuan Zhang Primary cardiac lymphoma: a clinicopathological study of 121 cases Frontiers in Oncology primary cardiac lymphoma diffuse large B-cell lymphoma diagnosis treatment prognosis |
| title | Primary cardiac lymphoma: a clinicopathological study of 121 cases |
| title_full | Primary cardiac lymphoma: a clinicopathological study of 121 cases |
| title_fullStr | Primary cardiac lymphoma: a clinicopathological study of 121 cases |
| title_full_unstemmed | Primary cardiac lymphoma: a clinicopathological study of 121 cases |
| title_short | Primary cardiac lymphoma: a clinicopathological study of 121 cases |
| title_sort | primary cardiac lymphoma a clinicopathological study of 121 cases |
| topic | primary cardiac lymphoma diffuse large B-cell lymphoma diagnosis treatment prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1509100/full |
| work_keys_str_mv | AT shuhuizhuang primarycardiaclymphomaaclinicopathologicalstudyof121cases AT liudichang primarycardiaclymphomaaclinicopathologicalstudyof121cases AT liudichang primarycardiaclymphomaaclinicopathologicalstudyof121cases AT xiaoxifeng primarycardiaclymphomaaclinicopathologicalstudyof121cases AT xiaoxifeng primarycardiaclymphomaaclinicopathologicalstudyof121cases AT weiwenhu primarycardiaclymphomaaclinicopathologicalstudyof121cases AT weiwenhu primarycardiaclymphomaaclinicopathologicalstudyof121cases AT zhaoboyang primarycardiaclymphomaaclinicopathologicalstudyof121cases AT yuanyuanzhang primarycardiaclymphomaaclinicopathologicalstudyof121cases |