Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders

Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders

Abstract Hematopoietic stem cells (HSCs) are critical for maintaining lifelong blood production and immune function, especially in the context of bone marrow transplantation, where their ability to reconstruct multiple blood lineages is essential. However, recent studies have revealed that certain H...

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Bibliographic Details
Main Authors: Yalu Chen, Jianqiao Shentu, Hanqi Lou, Yongming Xia, Yinyan Jiang, Shiwei Duan
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Stem Cell Research & Therapy
Subjects:
Lineage bias
Platelet-biased HSCs
Bone marrow transplantation
Blood disorders
Therapeutic strategies
Online Access:https://doi.org/10.1186/s13287-024-04084-6
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