Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy

Abstract Background The modulation of tumor microenvironments through immune checkpoint pathways is pivotal for the development of effective cancer immunotherapies. This study aims to explore the role of HVEM in non-small cell lung cancer (NSCLC) microenvironment. Methods The lung cancer datasets fo...

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Bibliographic Details
Main Authors: Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Cancer Immunology, Immunotherapy
Subjects:
HVEM
NSCLC
Jurkat cells
Immunotherapy
Online Access:https://doi.org/10.1007/s00262-025-03949-w
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