Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells

Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells

BackgroundThe insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyroid eye disease (TED). Effective therapeutic treatment of TED inhibits activation of the IGF-1R/TSH-...

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Bibliographic Details
Main Authors: Maximilian Luffy, Anna-Lena Ganz, Stefanie Wagner, Jan Wolf, Julian Ropertz, Ryan Zeidan, Jeffrey D. Kent, Raymond S. Douglas, George J. Kahaly
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
Linsitinib
small molecule kinase inhibitor
insulin-like growth factor 1 receptor
thyrotropin receptor
thyroid eye disease
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1488220/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1488220/full

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