Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au Nanocomposites
Prostate-specific antigen (PSA) is a well-established tumour marker for prostatic carcinoma. In this study, we present a novel, real-time, and ultrasensitive Love-mode surface acoustic wave (L-SAW) immunosensor for PSA detection enhanced by MoS<sub>2</sub>@Cu<sub>2</sub>O-Au...
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2024-11-01
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| author | Yan Yu Haiyu Xie Tao Zhou Haonan Zhang Chenze Lu Ran Tao Zhaozhao Tang Jingting Luo |
| author_facet | Yan Yu Haiyu Xie Tao Zhou Haonan Zhang Chenze Lu Ran Tao Zhaozhao Tang Jingting Luo |
| author_sort | Yan Yu |
| collection | DOAJ |
| description | Prostate-specific antigen (PSA) is a well-established tumour marker for prostatic carcinoma. In this study, we present a novel, real-time, and ultrasensitive Love-mode surface acoustic wave (L-SAW) immunosensor for PSA detection enhanced by MoS<sub>2</sub>@Cu<sub>2</sub>O-Au nanocomposite conjugation. The MoS<sub>2</sub>@Cu<sub>2</sub>O-Au nanocomposites were analyzed by SEM, XRD, and EDS. The experiments show a significant improvement in sensitivity and detection limit compared with the previous detection methods utilizing nanogold alone to detect PSA biomolecules. The experimental results show a good linear relationship when the range of PSA concentrations between 200 pg/mL and 5 ng/mL was tested. The experimental results also show good specificity against alpha 1 fetoprotein and L-tryptophan disruptors. |
| format | Article |
| id | doaj-art-e90f6eef8c644a63955f4b8f5fe41a7f |
| institution | Kabale University |
| issn | 1424-8220 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj-art-e90f6eef8c644a63955f4b8f5fe41a7f2024-12-13T16:32:14ZengMDPI AGSensors1424-82202024-11-012423763610.3390/s24237636Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au NanocompositesYan Yu0Haiyu Xie1Tao Zhou2Haonan Zhang3Chenze Lu4Ran Tao5Zhaozhao Tang6Jingting Luo7Shenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, ChinaShenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, ChinaShenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, ChinaShenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, ChinaKey Laboratory of Specialty Agri-Products Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University, Hangzhou 310018, ChinaShenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, ChinaWater Science and Environmental Engineering Research Centre, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, ChinaShenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, ChinaProstate-specific antigen (PSA) is a well-established tumour marker for prostatic carcinoma. In this study, we present a novel, real-time, and ultrasensitive Love-mode surface acoustic wave (L-SAW) immunosensor for PSA detection enhanced by MoS<sub>2</sub>@Cu<sub>2</sub>O-Au nanocomposite conjugation. The MoS<sub>2</sub>@Cu<sub>2</sub>O-Au nanocomposites were analyzed by SEM, XRD, and EDS. The experiments show a significant improvement in sensitivity and detection limit compared with the previous detection methods utilizing nanogold alone to detect PSA biomolecules. The experimental results show a good linear relationship when the range of PSA concentrations between 200 pg/mL and 5 ng/mL was tested. The experimental results also show good specificity against alpha 1 fetoprotein and L-tryptophan disruptors.https://www.mdpi.com/1424-8220/24/23/7636Love-mode surface acoustic wave (L-SAW)immunosensornanocompositeprostate-specific antigen (PSA)real timeultrasensitive |
| spellingShingle | Yan Yu Haiyu Xie Tao Zhou Haonan Zhang Chenze Lu Ran Tao Zhaozhao Tang Jingting Luo Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au Nanocomposites Sensors Love-mode surface acoustic wave (L-SAW) immunosensor nanocomposite prostate-specific antigen (PSA) real time ultrasensitive |
| title | Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au Nanocomposites |
| title_full | Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au Nanocomposites |
| title_fullStr | Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au Nanocomposites |
| title_full_unstemmed | Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au Nanocomposites |
| title_short | Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au Nanocomposites |
| title_sort | real time and ultrasensitive prostate specific antigen sensing using love mode surface acoustic wave immunosensor based on mos sub 2 sub cu sub 2 sub o au nanocomposites |
| topic | Love-mode surface acoustic wave (L-SAW) immunosensor nanocomposite prostate-specific antigen (PSA) real time ultrasensitive |
| url | https://www.mdpi.com/1424-8220/24/23/7636 |
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