The method of targeted delivery of drugs to the posterior segment of the eye
<br> Egorov A.E.<sup>1,2</sup>, Kats D.V.<sup>1,2</sup>, Baeva N.G.<sup>1,2</sup>, Movsyasyan A.B. <sup>1</sup><br> <br> <sup>1</sup> Pirogov Russian National Research Medical University, Moscow<br> <sup>2&...
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2018-07-01
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| Series: | РМЖ "Клиническая офтальмология" |
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| author | A.E. Egorov D.V. Katz Baeva N.G A.B. Movsisyan |
| author_facet | A.E. Egorov D.V. Katz Baeva N.G A.B. Movsisyan |
| author_sort | A.E. Egorov |
| collection | DOAJ |
| description | <br>
Egorov A.E.<sup>1,2</sup>, Kats D.V.<sup>1,2</sup>, Baeva N.G.<sup>1,2</sup>, Movsyasyan A.B. <sup>1</sup><br>
<br>
<sup>1</sup> Pirogov Russian National Research Medical University, Moscow<br>
<sup>2</sup> Municipal Clinical Hospital № 15 named after O.M. Filatov, Moscow<br>
<br>
<b>Aim</b>: to analyze the dynamics of patients’ visual functions with primary open-angle glaucoma (POAG) with preserved visual functions (PVF) and compensated intraocular pressure (IOP) after conducting trophic modified laser coagulation (tMLC).<br>
<b>Patients and methods:</b> the study included 67 patients (97 eyes) with moderate and advanced stages of open-angle glaucoma and normalized intraocular pressure. The examination for all patients included: anamnesis of disease, life, also a comprehensive ophthalmological examination was carried out, including visual acuity, tonometry, biomicroscopy, automated perimetry using kinetic visual field and central threshold test.<br>
In the study, patients were examined 4 times: before treatment, 5 days after tMLC, 1 month after tMLC and 5 month after tMLC.<br>
Trophic modified laser coagulation was performed in two stages: the creation of zones of increased permeability blood-ocular barrier (BOB) and the injection of the drug in that area.<br>
<b>Results</b>: patients with compensated POAG and PVF after conducting tMLC observed improvement of visual fields and patients noted subjective contrast enhancement of the image.<br>
Evaluation of average visual acuity data revealed an increase for 45.2% in a month after the treatment. The analysis of computer perimetry data revealed an extension of peripheral visual fields by 6.9% on average compared to the original ones.<br>
<b>Conclusion</b>: the research suggest the effectiveness, safety and prospective use tMLC as neuroretinoprotective therapy in patients with compensated POAG and PVF, it is provided that a stable and uniform reception of the drug to almost inaccessible structures of the posterior segment of the eye by overcoming blood-ocular barrier.<br>
<br>
<b>Key words:</b> primary open-angle glaucoma, optic neuropathy glaucoma, neuroretinoprotection, trophic modified coagulation.<br>
<b>For citation: </b>Egorov A.E., Kats D.V., Baeva N.G., Movsyasyan A.B. The method of targeted delivery of drugs to the posterior segment of the eye // RMJ “Clinical ophthalmology”. 2018;1:26–29.<br>
<br> |
| format | Article |
| id | doaj-art-e8fea061dc72420c961e643e09254168 |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2018-07-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-e8fea061dc72420c961e643e092541682025-01-16T09:39:39ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712018-07-0118110150The method of targeted delivery of drugs to the posterior segment of the eyeA.E. Egorov0D.V. Katz1Baeva N.G2A.B. Movsisyan3Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<br> Egorov A.E.<sup>1,2</sup>, Kats D.V.<sup>1,2</sup>, Baeva N.G.<sup>1,2</sup>, Movsyasyan A.B. <sup>1</sup><br> <br> <sup>1</sup> Pirogov Russian National Research Medical University, Moscow<br> <sup>2</sup> Municipal Clinical Hospital № 15 named after O.M. Filatov, Moscow<br> <br> <b>Aim</b>: to analyze the dynamics of patients’ visual functions with primary open-angle glaucoma (POAG) with preserved visual functions (PVF) and compensated intraocular pressure (IOP) after conducting trophic modified laser coagulation (tMLC).<br> <b>Patients and methods:</b> the study included 67 patients (97 eyes) with moderate and advanced stages of open-angle glaucoma and normalized intraocular pressure. The examination for all patients included: anamnesis of disease, life, also a comprehensive ophthalmological examination was carried out, including visual acuity, tonometry, biomicroscopy, automated perimetry using kinetic visual field and central threshold test.<br> In the study, patients were examined 4 times: before treatment, 5 days after tMLC, 1 month after tMLC and 5 month after tMLC.<br> Trophic modified laser coagulation was performed in two stages: the creation of zones of increased permeability blood-ocular barrier (BOB) and the injection of the drug in that area.<br> <b>Results</b>: patients with compensated POAG and PVF after conducting tMLC observed improvement of visual fields and patients noted subjective contrast enhancement of the image.<br> Evaluation of average visual acuity data revealed an increase for 45.2% in a month after the treatment. The analysis of computer perimetry data revealed an extension of peripheral visual fields by 6.9% on average compared to the original ones.<br> <b>Conclusion</b>: the research suggest the effectiveness, safety and prospective use tMLC as neuroretinoprotective therapy in patients with compensated POAG and PVF, it is provided that a stable and uniform reception of the drug to almost inaccessible structures of the posterior segment of the eye by overcoming blood-ocular barrier.<br> <br> <b>Key words:</b> primary open-angle glaucoma, optic neuropathy glaucoma, neuroretinoprotection, trophic modified coagulation.<br> <b>For citation: </b>Egorov A.E., Kats D.V., Baeva N.G., Movsyasyan A.B. The method of targeted delivery of drugs to the posterior segment of the eye // RMJ “Clinical ophthalmology”. 2018;1:26–29.<br> <br>http://clinopht.com/upload/iblock/3ef/3ef3e4045f8cd81a6427f8c5caacaa96.pdf |
| spellingShingle | A.E. Egorov D.V. Katz Baeva N.G A.B. Movsisyan The method of targeted delivery of drugs to the posterior segment of the eye РМЖ "Клиническая офтальмология" |
| title | The method of targeted delivery of drugs to the posterior segment of the eye |
| title_full | The method of targeted delivery of drugs to the posterior segment of the eye |
| title_fullStr | The method of targeted delivery of drugs to the posterior segment of the eye |
| title_full_unstemmed | The method of targeted delivery of drugs to the posterior segment of the eye |
| title_short | The method of targeted delivery of drugs to the posterior segment of the eye |
| title_sort | method of targeted delivery of drugs to the posterior segment of the eye |
| url | http://clinopht.com/upload/iblock/3ef/3ef3e4045f8cd81a6427f8c5caacaa96.pdf |
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