Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications
Due to their capacity to fight apoptosis, inflammation, and oxidative stress, naringin and its aglycone naringenin are considered valuable therapeutic agents for diabetes mellitus (DM). By examining clinical, in vitro, and in vivo studies found from inception until July 2024 on major electronic data...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006467 |
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| author | Soroush Fotouhi Aida Yavari Amir Reza Bagheri Vahid Reza Askari Yazdan Gholami Vafa Baradaran Rahimi |
| author_facet | Soroush Fotouhi Aida Yavari Amir Reza Bagheri Vahid Reza Askari Yazdan Gholami Vafa Baradaran Rahimi |
| author_sort | Soroush Fotouhi |
| collection | DOAJ |
| description | Due to their capacity to fight apoptosis, inflammation, and oxidative stress, naringin and its aglycone naringenin are considered valuable therapeutic agents for diabetes mellitus (DM). By examining clinical, in vitro, and in vivo studies found from inception until July 2024 on major electronic databases, we explored the pharmacological activities of naringin and naringenin in treating DM and associated risks. Naringin and naringenin improved insulin sensitivity, glucose metabolism, and insulin resistance by activating glucose transporter (GLUT)-4, and peroxisome proliferator-activated receptor (PPAR)-γ. They also possessed antioxidant and anti-inflammatory impacts through regulating mitogen-activated protein kinases (MAPK), nuclear factor kappa B (NF-κB), and Nrf2 signaling pathways. The obtained data emphasizes their role in protecting against heart, neuropathy, nephropathy, gastrointestinal tract, testicles, and skin diabetic complications. Naringin and naringenin could be developed as novel therapeutic options for treating DM, and the knowledge acquired from this review could be a valuable tool for future research projects. |
| format | Article |
| id | doaj-art-e8e0491db40149cdb919f7a7f2932d78 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-e8e0491db40149cdb919f7a7f2932d782025-01-12T05:24:46ZengElsevierJournal of Functional Foods1756-46462025-01-01124106643Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complicationsSoroush Fotouhi0Aida Yavari1Amir Reza Bagheri2Vahid Reza Askari3Yazdan Gholami4Vafa Baradaran Rahimi5Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author at: Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Sq, Vakil Abad Highway, Mashhad, Iran.Due to their capacity to fight apoptosis, inflammation, and oxidative stress, naringin and its aglycone naringenin are considered valuable therapeutic agents for diabetes mellitus (DM). By examining clinical, in vitro, and in vivo studies found from inception until July 2024 on major electronic databases, we explored the pharmacological activities of naringin and naringenin in treating DM and associated risks. Naringin and naringenin improved insulin sensitivity, glucose metabolism, and insulin resistance by activating glucose transporter (GLUT)-4, and peroxisome proliferator-activated receptor (PPAR)-γ. They also possessed antioxidant and anti-inflammatory impacts through regulating mitogen-activated protein kinases (MAPK), nuclear factor kappa B (NF-κB), and Nrf2 signaling pathways. The obtained data emphasizes their role in protecting against heart, neuropathy, nephropathy, gastrointestinal tract, testicles, and skin diabetic complications. Naringin and naringenin could be developed as novel therapeutic options for treating DM, and the knowledge acquired from this review could be a valuable tool for future research projects.http://www.sciencedirect.com/science/article/pii/S1756464624006467NaringinNaringeninDiabetes mellitusInflammationOxidative stress |
| spellingShingle | Soroush Fotouhi Aida Yavari Amir Reza Bagheri Vahid Reza Askari Yazdan Gholami Vafa Baradaran Rahimi Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications Journal of Functional Foods Naringin Naringenin Diabetes mellitus Inflammation Oxidative stress |
| title | Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications |
| title_full | Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications |
| title_fullStr | Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications |
| title_full_unstemmed | Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications |
| title_short | Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications |
| title_sort | exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications |
| topic | Naringin Naringenin Diabetes mellitus Inflammation Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006467 |
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