Preclinical evaluation of a universal inactivated influenza B vaccine based on the mosaic hemagglutinin-approach

Preclinical evaluation of a universal inactivated influenza B vaccine based on the mosaic hemagglutinin-approach

Abstract We have developed a new universal influenza B vaccination strategy based on inactivated influenza B viruses displaying mosaic hemagglutinins (mHAs). Recombinant mHA viruses were constructed by replacing the four major antigenic sites of influenza B virus HAs, with those from exotic avian in...

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Main Authors: Irene González-Domínguez, Eduard Puente-Massaguer, Adam Abdeljawad, Tsoi Ying Lai, Yonghong Liu, Madhumathi Loganathan, Benjamin Francis, Nicholas Lemus, Victoria Dolange, Marta Boza, Stefan Slamanig, Jose Luis Martínez-Guevara, Florian Krammer, Peter Palese, Weina Sun
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-01014-8
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https://doi.org/10.1038/s41541-024-01014-8

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