Bortezomib a safety treatment for patients with Multiple Myeloma and Cystic Fibrosis
<p><strong>Introduction: </strong>Bortezomib is a proteasome inhibitor that targets myeloma cell and its bone marrow micro-environment. Intravenous Bortezomib (1.3 mg/m<sup>2</sup> administered on days 1,4,8 and 11 of a 21 day cyc...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2012-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/article/view/10316 |
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| author | Fabiana Gentilini Anna Levi Vincenzo Federico Eleonora Russo Robin Foà Maria Teresa Petrucci |
| author_facet | Fabiana Gentilini Anna Levi Vincenzo Federico Eleonora Russo Robin Foà Maria Teresa Petrucci |
| author_sort | Fabiana Gentilini |
| collection | DOAJ |
| description | <p><strong>Introduction: </strong>Bortezomib is a proteasome inhibitor that targets myeloma cell and its bone marrow micro-environment. Intravenous Bortezomib (1.3 mg/m<sup>2</sup> administered on days 1,4,8 and 11 of a 21 day cycle), with or without dexamethasone, is effective and well tolerated in patients with relapsed/refractory multiple myeloma (MM).</p><p><strong>Methods: </strong>We treated a MM patient with<strong> </strong>Cystic Fibrosis with Bortezomib alone to avoid the use of corticosteroid and consequently the risk of lung infection reactivations, first of all due to the patient <em>Pseudomonas aeruginosa</em> colonization. Bortezomib was administrated at 1.3 mg/m<sup>2</sup> on days 1,4,8 and 11 with a 10 day rest period and four 21-day cycles were administered. We evaluate the treatment response and toxicity.</p><p><strong>Results: </strong>After four cycles of therapy the patient achieved a<strong> </strong>very good partial response (VGPR) according to the IMWG response criteria, without clinically significant side effects.</p><p><strong>Conclusions:</strong> Bortezomib can be successfully utilized for the management of this difficult disease situation</p> |
| format | Article |
| id | doaj-art-e8b9d3397d0e46b0a1e05bd46481bbab |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-e8b9d3397d0e46b0a1e05bd46481bbab2025-01-02T01:46:48ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062012-01-0141e2012035e2012035Bortezomib a safety treatment for patients with Multiple Myeloma and Cystic FibrosisFabiana GentiliniAnna LeviVincenzo FedericoEleonora RussoRobin FoàMaria Teresa Petrucci<p><strong>Introduction: </strong>Bortezomib is a proteasome inhibitor that targets myeloma cell and its bone marrow micro-environment. Intravenous Bortezomib (1.3 mg/m<sup>2</sup> administered on days 1,4,8 and 11 of a 21 day cycle), with or without dexamethasone, is effective and well tolerated in patients with relapsed/refractory multiple myeloma (MM).</p><p><strong>Methods: </strong>We treated a MM patient with<strong> </strong>Cystic Fibrosis with Bortezomib alone to avoid the use of corticosteroid and consequently the risk of lung infection reactivations, first of all due to the patient <em>Pseudomonas aeruginosa</em> colonization. Bortezomib was administrated at 1.3 mg/m<sup>2</sup> on days 1,4,8 and 11 with a 10 day rest period and four 21-day cycles were administered. We evaluate the treatment response and toxicity.</p><p><strong>Results: </strong>After four cycles of therapy the patient achieved a<strong> </strong>very good partial response (VGPR) according to the IMWG response criteria, without clinically significant side effects.</p><p><strong>Conclusions:</strong> Bortezomib can be successfully utilized for the management of this difficult disease situation</p>http://www.mjhid.org/article/view/10316Multiple Myeloma, Cystic Fibrosis, Bortezomib |
| spellingShingle | Fabiana Gentilini Anna Levi Vincenzo Federico Eleonora Russo Robin Foà Maria Teresa Petrucci Bortezomib a safety treatment for patients with Multiple Myeloma and Cystic Fibrosis Mediterranean Journal of Hematology and Infectious Diseases Multiple Myeloma, Cystic Fibrosis, Bortezomib |
| title | Bortezomib a safety treatment for patients with Multiple Myeloma and Cystic Fibrosis |
| title_full | Bortezomib a safety treatment for patients with Multiple Myeloma and Cystic Fibrosis |
| title_fullStr | Bortezomib a safety treatment for patients with Multiple Myeloma and Cystic Fibrosis |
| title_full_unstemmed | Bortezomib a safety treatment for patients with Multiple Myeloma and Cystic Fibrosis |
| title_short | Bortezomib a safety treatment for patients with Multiple Myeloma and Cystic Fibrosis |
| title_sort | bortezomib a safety treatment for patients with multiple myeloma and cystic fibrosis |
| topic | Multiple Myeloma, Cystic Fibrosis, Bortezomib |
| url | http://www.mjhid.org/article/view/10316 |
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