Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020
"Purpose: To describe the incidence and mortality of upper tract urothelial carcinoma (UTUC) from 2002–2020 using data from the Korean National Health Insurance Service, which contains data from the entire Korean population. Materials and Methods: Reimbursement records for 43,255 patients diag...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2025-01-01
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| Series: | Investigative and Clinical Urology |
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| Online Access: | https://www.icurology.org/pdf/10.4111/icu.20240255 |
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| author | Seongmin Moon Yun-Sok Ha Mina Kim Hoseob Kim Won Tae Kim Yong-June Kim Seok-Joong Yun Sang-Cheol Lee Ho Won Kang |
| author_facet | Seongmin Moon Yun-Sok Ha Mina Kim Hoseob Kim Won Tae Kim Yong-June Kim Seok-Joong Yun Sang-Cheol Lee Ho Won Kang |
| author_sort | Seongmin Moon |
| collection | DOAJ |
| description | "Purpose: To describe the incidence and mortality of upper tract urothelial carcinoma (UTUC) from 2002–2020 using data from the Korean National Health Insurance Service, which contains data from the entire Korean population.
Materials and Methods: Reimbursement records for 43,255 patients diagnosed with primary UTUC (according to the International Classification of Disease 10th revision code C65 and C66) between 2002–2020 were retrieved. The study period was split into four: period I (2002–2005), period II (2006–2010), period III (2011–2015), and period IV (2016–2020). Trends were quantified by calculating the annual percentage change (APC). Mortality data were obtained from the Statistics Korea.
Results: From 2002–2020, the incidence of UTUC in Korea increased gradually from 9.34 to 11.40 per 100,000 person-years. Although there was a male predominance, the male to female ratio did not change significantly over time; however, age at the time of diagnosis, the comorbidity index, and the proportion of patients undergoing open/laparoscopic surgery increased significantly over time. There was a modest improvement in 5-year survival (both all cause- and cancer-specific) over the study period. Multivariate analysis identified age at diagnosis, sex, the comorbidity index, and open/laparoscopic surgery as being associated with survival.
Conclusions: Between 2002 and 2020, the incidence of UTUC in Korea showed a general upward trend; however, survival outcomes have improved. These representative datasets from the Korean population might provide crucial information that enables clinicians to better understand of the epidemiology of UTUC in Korea."
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| format | Article |
| id | doaj-art-e8b4609d90f94a938eb3732562ae96d4 |
| institution | Kabale University |
| issn | 2466-0493 2466-054X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj-art-e8b4609d90f94a938eb3732562ae96d42025-01-09T09:05:38ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2025-01-01661111710.4111/icu.20240255Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020Seongmin Moon0https://orcid.org/0009-0003-7090-5067 Yun-Sok Ha1https://orcid.org/0000-0003-3732-9814Mina Kim2https://orcid.org/0000-0003-3180-4565Hoseob Kim3https://orcid.org/0000-0003-3063-8024 Won Tae Kim4https://orcid.org/0000-0002-7482-4550Yong-June Kim5https://orcid.org/0000-0001-7638-7174 Seok-Joong Yun6https://orcid.org/0000-0001-7737-4746 Sang-Cheol Lee7https://orcid.org/0000-0002-4163-2210Ho Won Kang8https://orcid.org/0000-0002-8164-4427Department of Urology, Chungbuk National University Hospital, Cheongju, Korea.Department of Urology, Kyungpook National University Hospital, Daegu, Korea.Department of Data Science, Hanmi Pharmaceutical Co., Ltd., Seoul, Korea.Department of Data Science, Hanmi Pharmaceutical Co., Ltd., Seoul, Korea.Department of Urology, Chungbuk National University Hospital, Cheongju, Korea.Department of Urology, Chungbuk National University Hospital, Cheongju, Korea.Department of Urology, Chungbuk National University Hospital, Cheongju, Korea.Department of Urology, Chungbuk National University Hospital, Cheongju, Korea.Department of Urology, Chungbuk National University Hospital, Cheongju, Korea."Purpose: To describe the incidence and mortality of upper tract urothelial carcinoma (UTUC) from 2002–2020 using data from the Korean National Health Insurance Service, which contains data from the entire Korean population. Materials and Methods: Reimbursement records for 43,255 patients diagnosed with primary UTUC (according to the International Classification of Disease 10th revision code C65 and C66) between 2002–2020 were retrieved. The study period was split into four: period I (2002–2005), period II (2006–2010), period III (2011–2015), and period IV (2016–2020). Trends were quantified by calculating the annual percentage change (APC). Mortality data were obtained from the Statistics Korea. Results: From 2002–2020, the incidence of UTUC in Korea increased gradually from 9.34 to 11.40 per 100,000 person-years. Although there was a male predominance, the male to female ratio did not change significantly over time; however, age at the time of diagnosis, the comorbidity index, and the proportion of patients undergoing open/laparoscopic surgery increased significantly over time. There was a modest improvement in 5-year survival (both all cause- and cancer-specific) over the study period. Multivariate analysis identified age at diagnosis, sex, the comorbidity index, and open/laparoscopic surgery as being associated with survival. Conclusions: Between 2002 and 2020, the incidence of UTUC in Korea showed a general upward trend; however, survival outcomes have improved. These representative datasets from the Korean population might provide crucial information that enables clinicians to better understand of the epidemiology of UTUC in Korea." https://www.icurology.org/pdf/10.4111/icu.20240255incidencenational health insurancesurvivalureteral neoplasms |
| spellingShingle | Seongmin Moon Yun-Sok Ha Mina Kim Hoseob Kim Won Tae Kim Yong-June Kim Seok-Joong Yun Sang-Cheol Lee Ho Won Kang Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020 Investigative and Clinical Urology incidence national health insurance survival ureteral neoplasms |
| title | Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020 |
| title_full | Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020 |
| title_fullStr | Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020 |
| title_full_unstemmed | Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020 |
| title_short | Incidence and mortality of upper tract urothelial carcinoma in Korea: A nationwide population-based study conducted from 2002 to 2020 |
| title_sort | incidence and mortality of upper tract urothelial carcinoma in korea a nationwide population based study conducted from 2002 to 2020 |
| topic | incidence national health insurance survival ureteral neoplasms |
| url | https://www.icurology.org/pdf/10.4111/icu.20240255 |
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