TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein

TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein

Abstract As an acute respiratory infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19) exhibits remarkable contagiousness and has emerged as a critical global public health concern. In critically ill patients, virus-induced cyt...

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Bibliographic Details
Main Authors: Simin Zhu, Wei Li, Yuqiu Hao, Lin Zhang, Peng Gao
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
TIPE2
SARS-CoV-2 spike protein
COVID-19
Macrophage polarization
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-025-14235-1
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https://doi.org/10.1038/s41598-025-14235-1

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