Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application
Abstract Hepatocellular carcinoma (HCC) is a primary malignant tumour, ranking second in global mortality rates and posing significant health threats. Epigenetic alterations, particularly DNA methylation, have emerged as pivotal factors associated with HCC diagnosis, therapy, prognosis and malignant...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Clinical and Translational Medicine |
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| Online Access: | https://doi.org/10.1002/ctm2.70066 |
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| author | Lin Su Jiawen Bu Jiahui Yu Mila Jin Guanliang Meng Xudong Zhu |
| author_facet | Lin Su Jiawen Bu Jiahui Yu Mila Jin Guanliang Meng Xudong Zhu |
| author_sort | Lin Su |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) is a primary malignant tumour, ranking second in global mortality rates and posing significant health threats. Epigenetic alterations, particularly DNA methylation, have emerged as pivotal factors associated with HCC diagnosis, therapy, prognosis and malignant progression. However, a comprehensive analysis of the DNA methylation mechanism driving HCC progression and its potential as a therapeutic biomarker remains lacking. This review attempts to comprehensively summarise various aspects of DNA methylation, such as its mechanism, detection methods and biomarkers aiding in HCC diagnosis, treatment and prognostic assessment of HCC. It also explores the role of DNA methylation in regulating HCC's malignant progression and sorafenib resistance, alongside elaborating the therapeutic effects of DNA methyltransferase inhibitors on HCC. A detailed examination of these aspects underscores the significant research on DNA methylation in tumour cells to elucidate malignant progression mechanisms, identify diagnostic markers and develop new tumour‐specific inhibitors for HCC. Key points A comprehensive summary of various aspects of DNA methylation, such as its mechanism, detection methods and biomarkers aiding in diagnosis and treatment. The role of DNA methylation in regulating hepatocellular carcinoma's (HCC) malignant progression and sorafenib resistance, alongside elaborating therapeutic effects of DNA methyltransferase inhibitors. Deep research on DNA methylation is critical for discovering novel tumour‐specific inhibitors for HCC. |
| format | Article |
| id | doaj-art-e8b0bd0c0ba04f2a8cd1fe3369fa7fe0 |
| institution | Kabale University |
| issn | 2001-1326 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj-art-e8b0bd0c0ba04f2a8cd1fe3369fa7fe02024-12-05T05:48:38ZengWileyClinical and Translational Medicine2001-13262024-11-011411n/an/a10.1002/ctm2.70066Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical applicationLin Su0Jiawen Bu1Jiahui Yu2Mila Jin3Guanliang Meng4Xudong Zhu5Department of Pain Management Shengjing Hospital of China Medical University Shenyang Liaoning ChinaDepartment of Colorectal Surgery Shengjing Hospital of China Medical University Shenyang Liaoning ChinaDepartment of Ultrasound Shengjing Hospital of China Medical University Shenyang Liaoning ChinaDepartment of Operation Room The First Hospital of China Medical University Shenyang Liaoning ChinaDepartment of Urology Shengjing Hospital of China Medical University Shenyang Liaoning ChinaDepartment of Oncology Shengjing Hospital of China Medical University Shenyang Liaoning ChinaAbstract Hepatocellular carcinoma (HCC) is a primary malignant tumour, ranking second in global mortality rates and posing significant health threats. Epigenetic alterations, particularly DNA methylation, have emerged as pivotal factors associated with HCC diagnosis, therapy, prognosis and malignant progression. However, a comprehensive analysis of the DNA methylation mechanism driving HCC progression and its potential as a therapeutic biomarker remains lacking. This review attempts to comprehensively summarise various aspects of DNA methylation, such as its mechanism, detection methods and biomarkers aiding in HCC diagnosis, treatment and prognostic assessment of HCC. It also explores the role of DNA methylation in regulating HCC's malignant progression and sorafenib resistance, alongside elaborating the therapeutic effects of DNA methyltransferase inhibitors on HCC. A detailed examination of these aspects underscores the significant research on DNA methylation in tumour cells to elucidate malignant progression mechanisms, identify diagnostic markers and develop new tumour‐specific inhibitors for HCC. Key points A comprehensive summary of various aspects of DNA methylation, such as its mechanism, detection methods and biomarkers aiding in diagnosis and treatment. The role of DNA methylation in regulating hepatocellular carcinoma's (HCC) malignant progression and sorafenib resistance, alongside elaborating therapeutic effects of DNA methyltransferase inhibitors. Deep research on DNA methylation is critical for discovering novel tumour‐specific inhibitors for HCC.https://doi.org/10.1002/ctm2.70066DNA methylationDNA methyltransferasehepatocellular carcinomainhibitorsmalignant progressionsorafenib resistance |
| spellingShingle | Lin Su Jiawen Bu Jiahui Yu Mila Jin Guanliang Meng Xudong Zhu Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application Clinical and Translational Medicine DNA methylation DNA methyltransferase hepatocellular carcinoma inhibitors malignant progression sorafenib resistance |
| title | Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application |
| title_full | Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application |
| title_fullStr | Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application |
| title_full_unstemmed | Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application |
| title_short | Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application |
| title_sort | comprehensive review and updated analysis of dna methylation in hepatocellular carcinoma from basic research to clinical application |
| topic | DNA methylation DNA methyltransferase hepatocellular carcinoma inhibitors malignant progression sorafenib resistance |
| url | https://doi.org/10.1002/ctm2.70066 |
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