Late‐Stage Skeletal Muscle Transcriptome in Duchenne Muscular Dystrophy Shows a BMP4‐Induced Molecular Signature

Late‐Stage Skeletal Muscle Transcriptome in Duchenne Muscular Dystrophy Shows a BMP4‐Induced Molecular Signature

ABSTRACT Background Duchenne muscular dystrophy (DMD) is a fatal X‐linked recessive disease due to loss‐of‐function variants in the DYSTROPHIN gene. DMD‐related skeletal muscle wasting is typified by an aberrant immune response involving upregulation of the TGFβ family of cytokines, like TGFβ1 and B...

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Bibliographic Details
Main Authors: Hanna Sothers, Xianzhen Hu, David K. Crossman, Ying Si, Matthew S. Alexander, Merry‐Lynn N. McDonald, Peter H. King, Michael A. Lopez
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
BMP4
Duchenne muscular dystrophy
SMAD8
TGFβ1
Online Access:https://doi.org/10.1002/jcsm.70005
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