HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis

HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis

Introduction: Cardiac fibrosis is the main driver for adverse remodeling and progressive functional decline in nearly all types of heart disease including myocardial infarction (MI). The activation of cardiac fibroblasts (CF) into myofibroblasts is responsible for cardiac fibrosis. Unfortunately, no...

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Bibliographic Details
Main Authors: Qian Mao, Xiaojin Zhang, Jinna Yang, Qiuyue Kong, Hao Cheng, Wansu Yu, Xiaofei Cao, Yuehua Li, Chuanfu Li, Li Liu, Zhengnian Ding
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Journal of Advanced Research
Subjects:
Cardiac fibroblast activation
Cardiac fibrosis
HSPA12A
Glycolysis
P53
USP10
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224000250
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