Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung

Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung

Abstract Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors. To address this, we develop an anti-PD-L1-expressing nanovesicle loaded with the STING agonist cGAMP (aPD-L1 NVs@...

Full description

Saved in:
Bibliographic Details
Main Authors: Tianchuan Zhu, Yuchen Xiao, Zhenxing Chen, Hanxi Ding, Shoudeng Chen, Guanmin Jiang, Xi Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55751-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items