SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression

SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression

Summary: Chondrocytes experience adverse lipid metabolism disorders during the degeneration of cartilage in osteoarthritis (OA), while the underlying mechanisms remain poorly understood. Sestrin2 (SESN2), a highly conserved stress-inducible protein, plays a crucial role in regulating lipid metabolis...

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Main Authors: Zizheng Liu, Huiming Jiang, Zhaofeng Zhang, Ruiyang Jiang, Rongliang Wang, Jiawei Li, Weitong Li, Guihua Tan, Yuxiang Fei, Zhongyang Lv, Hu Guo, Ziyin Sun, Rui Wu, Hongfei Shi, Dongquan Shi
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
natural sciences
biological sciences
biochemistry
physiology
pathophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013586
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