Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in Residents of Trujillo City, Peru
Cardiac troponin serum concentration is a marker of myocardial injury, but NT-pro BNP is a marker of myocardial insufficiency. The purpose of this study was to determine binary logistic regression models to verify the possible association of cardiovascular risk indicators, pre-pandemic history, the...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/2075-4418/14/22/2503 |
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| author | Joao Caballero-Vidal Jorge Luis Díaz-Ortega Irma Luz Yupari-Azabache Luz Angélica Castro-Caracholi Juan M. Alva Sevilla |
| author_facet | Joao Caballero-Vidal Jorge Luis Díaz-Ortega Irma Luz Yupari-Azabache Luz Angélica Castro-Caracholi Juan M. Alva Sevilla |
| author_sort | Joao Caballero-Vidal |
| collection | DOAJ |
| description | Cardiac troponin serum concentration is a marker of myocardial injury, but NT-pro BNP is a marker of myocardial insufficiency. The purpose of this study was to determine binary logistic regression models to verify the possible association of cardiovascular risk indicators, pre-pandemic history, the number of times participants were infected with SARS-CoV-2, and vaccination against these biomarkers. A total of 281 residents of Trujillo city (Peru) participated between September and December 2023. We found a high prevalence of abdominal obesity of 55.2%; glycemia > 100 m/dL in 53%; hypercholesterolemia in 49.8%; low HDL in 71.9%; and LDL > 100 mg/dL in 78.6%. A total of 97.5% were vaccinated against COVID-19, and 92.2% had three or more doses. Also, 2.5% had cTnI > 0.05 ng/mL, and 3.3% had NT-proBNP > 125 pg/mL. The number of COVID-19 infections versus cTnI > 0.05 ng/mL presented an OR = 3.513 (<i>p</i> = 0.003), while for NT-proBNP > 125 pg/mL, the number of comorbidities presented an OR = 2.185 (<i>p</i> = 0.025) and LDL an OR = 0.209 (<i>p</i> = 0.025). A regression model was obtained in which there is an association between a higher number of COVID-19 infections and elevated cTnI values and a model implying an association of the number of comorbidities and LDL with the NT-proBNP level in a direct and inverse manner, respectively. Both models contribute to the prevention of cardiac damage. |
| format | Article |
| id | doaj-art-e87a39aab2964db496e546b4e7ea3c02 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-e87a39aab2964db496e546b4e7ea3c022024-11-26T17:59:37ZengMDPI AGDiagnostics2075-44182024-11-011422250310.3390/diagnostics14222503Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in Residents of Trujillo City, PeruJoao Caballero-Vidal0Jorge Luis Díaz-Ortega1Irma Luz Yupari-Azabache2Luz Angélica Castro-Caracholi3Juan M. Alva Sevilla4Escuela Profesional de Nutrición, Universidad César Vallejo, Trujillo 13001, PeruEscuela Profesional de Nutrición, Universidad César Vallejo, Trujillo 13001, PeruInstitutos y Centros de Investigación, Universidad César Vallejo, Trujillo 13001, PeruEscuela Profesional de Nutrición, Universidad César Vallejo, Trujillo 13001, PeruEscuela Profesional de Medicina, Universidad César Vallejo, Trujillo 13001, PeruCardiac troponin serum concentration is a marker of myocardial injury, but NT-pro BNP is a marker of myocardial insufficiency. The purpose of this study was to determine binary logistic regression models to verify the possible association of cardiovascular risk indicators, pre-pandemic history, the number of times participants were infected with SARS-CoV-2, and vaccination against these biomarkers. A total of 281 residents of Trujillo city (Peru) participated between September and December 2023. We found a high prevalence of abdominal obesity of 55.2%; glycemia > 100 m/dL in 53%; hypercholesterolemia in 49.8%; low HDL in 71.9%; and LDL > 100 mg/dL in 78.6%. A total of 97.5% were vaccinated against COVID-19, and 92.2% had three or more doses. Also, 2.5% had cTnI > 0.05 ng/mL, and 3.3% had NT-proBNP > 125 pg/mL. The number of COVID-19 infections versus cTnI > 0.05 ng/mL presented an OR = 3.513 (<i>p</i> = 0.003), while for NT-proBNP > 125 pg/mL, the number of comorbidities presented an OR = 2.185 (<i>p</i> = 0.025) and LDL an OR = 0.209 (<i>p</i> = 0.025). A regression model was obtained in which there is an association between a higher number of COVID-19 infections and elevated cTnI values and a model implying an association of the number of comorbidities and LDL with the NT-proBNP level in a direct and inverse manner, respectively. Both models contribute to the prevention of cardiac damage.https://www.mdpi.com/2075-4418/14/22/2503natriuretic peptidecardiac troponin Imetabolic syndromecholesterolcomorbiditydyslipidemia |
| spellingShingle | Joao Caballero-Vidal Jorge Luis Díaz-Ortega Irma Luz Yupari-Azabache Luz Angélica Castro-Caracholi Juan M. Alva Sevilla Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in Residents of Trujillo City, Peru Diagnostics natriuretic peptide cardiac troponin I metabolic syndrome cholesterol comorbidity dyslipidemia |
| title | Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in Residents of Trujillo City, Peru |
| title_full | Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in Residents of Trujillo City, Peru |
| title_fullStr | Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in Residents of Trujillo City, Peru |
| title_full_unstemmed | Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in Residents of Trujillo City, Peru |
| title_short | Prediction Models for Elevated Cardiac Biomarkers from Previous Risk Factors and During the COVID-19 Pandemic in Residents of Trujillo City, Peru |
| title_sort | prediction models for elevated cardiac biomarkers from previous risk factors and during the covid 19 pandemic in residents of trujillo city peru |
| topic | natriuretic peptide cardiac troponin I metabolic syndrome cholesterol comorbidity dyslipidemia |
| url | https://www.mdpi.com/2075-4418/14/22/2503 |
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