High-affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells

High-affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells

Regulatory T cells (Tregs) are promising cellular therapies to induce immune tolerance in organ transplantation and autoimmune disease. The success of chimeric antigen receptor (CAR) T cell therapy for cancer has sparked interest in using CARs to generate antigen-specific Tregs. Here, we compared CA...

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Bibliographic Details
Main Authors: Russell W. Cochrane, Rob A. Robino, Bryan Granger, Eva Allen, Silvia Vaena, Martin J. Romeo, Aguirre A. de Cubas, Stefano Berto, Leonardo M.R. Ferreira
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
regulatory T cell
chimeric antigen receptor
receptor affinity
synthetic immunology
immune cell therapy
immune tolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124002018
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http://www.sciencedirect.com/science/article/pii/S2329050124002018

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