The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers

The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers

Sphingolipids, particularly sphingosine-1-phosphate (S1P), are bioactive lipids involved in regulating cellular processes such as proliferation, apoptosis, inflammation, and tumor progression. Alkaline ceramidase 2 (ACER2) plays a critical role in sphingolipid metabolism by catalyzing the hydrolysis...

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Bibliographic Details
Main Authors: Binggang Liu, Junfeng Zhou, Biao Jiang, Bing Tang, Ting Liu, Pengcheng Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
ACER2
ceramidase
gastrointestinal tumors
sphingolipid metabolism
inflammation
immune modulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1511283/full
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