Ribosome engineering of Myxococcus xanthus for enhancing the heterologous production of epothilones

Ribosome engineering of Myxococcus xanthus for enhancing the heterologous production of epothilones

Abstract Background Ribosome engineering is a semi-empirical technique used to select antibiotic-resistant mutants that exhibit altered secondary metabolism. This method has been demonstrated to effectively select mutants with enhanced synthesis of natural products in many bacterial species, includi...

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Main Authors: Xu Kang, Xiao-ran Yue, Chen-xi Wang, Jia-rui Wang, Jun-ning Zhao, Zhao-peng Yang, Qin-ke Fu, Chang-sheng Wu, Wei Hu, Yue-zhong Li, Xin-jing Yue
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Microbial Cell Factories
Subjects:
Ribosome engineering
Myxococcus xanthus
Secondary metabolism
Production of epothilones
Metabolic interference
Online Access:https://doi.org/10.1186/s12934-024-02627-3
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