Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study

Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study

Objectives The purpose of this study was to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) levels and endothelial function in women.Design Cross-sectional study.Setting 22 university hospitals and affiliated clinics in Japan.Participants 1719 Japanese women aged 17–90...

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Main Authors: Kazuaki Chayama, Yuji Takaeko, Shogo Matsui, Masato Kajikawa, Tatsuya Maruhashi, Takayuki Yamaji, Takahiro Harada, Yiming Han, Haruki Hashimoto, Yasuki Kihara, Eisuke Hida, Chikara Goto, Yoshiki Aibara, Farina Mohamad Yusoff, Shinji Kishimoto, Ayumu Nakashima, Yukihito Higashi
Format: Article
Language:English
Published: BMJ Publishing Group 2020-07-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/7/e038121.full
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Summary:Objectives The purpose of this study was to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) levels and endothelial function in women.Design Cross-sectional study.Setting 22 university hospitals and affiliated clinics in Japan.Participants 1719 Japanese women aged 17–90 years who were not receiving lipid-lowering therapy.Measures We evaluated flow-mediated vasodilation (FMD) and serum levels of HDL-C. All participants were divided into four groups by HDL-C level: low HDL-C (<40 mg/dL), moderate HDL-C (40–59 mg/dL), high HDL-C (60–79 md/dL) and extremely high HDL-C (≥80 mg/dL).Results Univariate regression analysis revealed a significant relationship between FMD and HDL-C (r=0.12, p<0.001). FMD values were significantly smaller in the low HDL-C group (5.2%±3.8%) and moderate HDL-C group (5.2%±3.8%) than in the extremely high HDL-C group (6.7%±3.4%) (p=0.024 and p=0.003, respectively), while there was no significant difference in FMD between the high HDL-C group and the extremely high HDL-C group. Multiple logistic regression analysis did not show a significant association between HDL-C levels and FMD.Conclusions Endothelial function increased in relation to HDL-C levels. However, there was no association of HDL-C levels with endothelial function after adjustment of traditional cardiovascular risk factors in women.Trial registration number UMIN000012950; Results.
ISSN:2044-6055

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