Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery
Objective To evaluate the effect of preoperative intravenous mannitol on the capsulorhexis process and intraoperative complications in patients with primary angle-closure glaucoma (PACG). Methods In this prospective randomized controlled trial, 65 PACG eyes were randomized into the mannitol and cont...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605241310106 |
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| author | Zhiqiao Liang Hongyan Li Xianru Hou Kangyi Yang Kun Lv Yao Ma Ye Lu Kuankuan Wu Huijuan Wu |
| author_facet | Zhiqiao Liang Hongyan Li Xianru Hou Kangyi Yang Kun Lv Yao Ma Ye Lu Kuankuan Wu Huijuan Wu |
| author_sort | Zhiqiao Liang |
| collection | DOAJ |
| description | Objective To evaluate the effect of preoperative intravenous mannitol on the capsulorhexis process and intraoperative complications in patients with primary angle-closure glaucoma (PACG). Methods In this prospective randomized controlled trial, 65 PACG eyes were randomized into the mannitol and control groups. The capsulorhexis duration, number of forceps grasps, need for viscoelastic re-injection, and intraoperative complications were recorded. Results The mannitol group had a significantly shorter capsulorhexis duration and fewer forceps grasps of the capsule. All intraoperative complications (18.2%) occurred in the control group. The patients with intraoperative complications had significantly higher intraocular pressure and lower best-corrected visual acuity than those without complications after surgery. Multivariate analysis found that intravenous mannitol (odds ratio [OR] = −14.263; 95% confidence interval [CI] =−26.713 to −1.813) reduced the capsulorhexis duration, whereas zonulopathy (OR = 14.477, 95% CI = 2.622–26.331) prolonged the duration. Conclusion Preoperative intravenous mannitol can reduce the risk of intraoperative complications and improve postoperative outcomes in patients with PACG. Factors including anterior chamber depth, incision location and method, and the zonule status significantly influence the capsulorhexis process. |
| format | Article |
| id | doaj-art-e7f558d2750f4f1f830e90600fb7e2fc |
| institution | Kabale University |
| issn | 1473-2300 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-e7f558d2750f4f1f830e90600fb7e2fc2025-01-16T11:03:52ZengSAGE PublishingJournal of International Medical Research1473-23002025-01-015310.1177/03000605241310106Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgeryZhiqiao LiangHongyan LiXianru HouKangyi YangKun LvYao MaYe LuKuankuan WuHuijuan WuObjective To evaluate the effect of preoperative intravenous mannitol on the capsulorhexis process and intraoperative complications in patients with primary angle-closure glaucoma (PACG). Methods In this prospective randomized controlled trial, 65 PACG eyes were randomized into the mannitol and control groups. The capsulorhexis duration, number of forceps grasps, need for viscoelastic re-injection, and intraoperative complications were recorded. Results The mannitol group had a significantly shorter capsulorhexis duration and fewer forceps grasps of the capsule. All intraoperative complications (18.2%) occurred in the control group. The patients with intraoperative complications had significantly higher intraocular pressure and lower best-corrected visual acuity than those without complications after surgery. Multivariate analysis found that intravenous mannitol (odds ratio [OR] = −14.263; 95% confidence interval [CI] =−26.713 to −1.813) reduced the capsulorhexis duration, whereas zonulopathy (OR = 14.477, 95% CI = 2.622–26.331) prolonged the duration. Conclusion Preoperative intravenous mannitol can reduce the risk of intraoperative complications and improve postoperative outcomes in patients with PACG. Factors including anterior chamber depth, incision location and method, and the zonule status significantly influence the capsulorhexis process.https://doi.org/10.1177/03000605241310106 |
| spellingShingle | Zhiqiao Liang Hongyan Li Xianru Hou Kangyi Yang Kun Lv Yao Ma Ye Lu Kuankuan Wu Huijuan Wu Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery Journal of International Medical Research |
| title | Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery |
| title_full | Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery |
| title_fullStr | Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery |
| title_full_unstemmed | Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery |
| title_short | Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery |
| title_sort | prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle closure disease surgery |
| url | https://doi.org/10.1177/03000605241310106 |
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