Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung Cancer
Lung cancer remains the most frequently diagnosed cancer and the leading cause of cancer-related death worldwide, with anaplastic lymphoma kinase (ALK) fusion mutations accounting for approximately 4%-9% of cases. In recent years, there are increasing clinical evidences suggesting that the combinati...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2024-11-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2024.106.30 |
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| _version_ | 1841544100220764160 |
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| author | Weizhen SUN Yuheng ZHOU Yaobin LIN Shoucheng FENG Hao LONG |
| author_facet | Weizhen SUN Yuheng ZHOU Yaobin LIN Shoucheng FENG Hao LONG |
| author_sort | Weizhen SUN |
| collection | DOAJ |
| description | Lung cancer remains the most frequently diagnosed cancer and the leading cause of cancer-related death worldwide, with anaplastic lymphoma kinase (ALK) fusion mutations accounting for approximately 4%-9% of cases. In recent years, there are increasing clinical evidences suggesting that the combination of ALK inhibitors with surgical treatment holds significant potential for clinical application in resectable early and locally advanced non-small cell lung cancer (NSCLC) patients. This review aims to summarize the advances in neoadjuvant targeted therapy for ALK fusion positive NSCLC and discuss its advantages and challenges in clinical practice. |
| format | Article |
| id | doaj-art-e7f270be5d25463e994b59744139c660 |
| institution | Kabale University |
| issn | 1009-3419 1999-6187 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj-art-e7f270be5d25463e994b59744139c6602025-01-13T02:46:02ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872024-11-01271184985410.3779/j.issn.1009-3419.2024.106.30Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung CancerWeizhen SUN0Yuheng ZHOU1Yaobin LIN2Shoucheng FENG3Hao LONG4Department of Thoracic Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China,
Guangzhou 510000, ChinaDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China,
Guangzhou 510000, ChinaDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China,
Guangzhou 510000, ChinaDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China,
Guangzhou 510000, ChinaDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China,
Guangzhou 510000, ChinaLung cancer remains the most frequently diagnosed cancer and the leading cause of cancer-related death worldwide, with anaplastic lymphoma kinase (ALK) fusion mutations accounting for approximately 4%-9% of cases. In recent years, there are increasing clinical evidences suggesting that the combination of ALK inhibitors with surgical treatment holds significant potential for clinical application in resectable early and locally advanced non-small cell lung cancer (NSCLC) patients. This review aims to summarize the advances in neoadjuvant targeted therapy for ALK fusion positive NSCLC and discuss its advantages and challenges in clinical practice.http://dx.doi.org/10.3779/j.issn.1009-3419.2024.106.30lung neoplasmsalk-positiveneoadjuvant therapytargeted therapy |
| spellingShingle | Weizhen SUN Yuheng ZHOU Yaobin LIN Shoucheng FENG Hao LONG Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung Cancer Chinese Journal of Lung Cancer lung neoplasms alk-positive neoadjuvant therapy targeted therapy |
| title | Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung Cancer |
| title_full | Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung Cancer |
| title_fullStr | Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung Cancer |
| title_full_unstemmed | Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung Cancer |
| title_short | Advances of Neoadjuvant Targeted Therapy in ALK-positive Non-small Cell Lung Cancer |
| title_sort | advances of neoadjuvant targeted therapy in alk positive non small cell lung cancer |
| topic | lung neoplasms alk-positive neoadjuvant therapy targeted therapy |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2024.106.30 |
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