Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system
Abstract Type 2 diabetes mellitus (T2DM) is a pivotal chronic disease with an increasing prevalence. Recent studies have found associations between T2DM and the development of central nervous system (CNS) tumours, a special class of solid tumours with an unclear pathogenesis. In this study, we aimed...
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| Language: | English |
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BMC
2024-11-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-024-03969-6 |
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| author | Yongxue Li Lihao Lin Wenhui Zhang Yan Wang Yi Guan |
| author_facet | Yongxue Li Lihao Lin Wenhui Zhang Yan Wang Yi Guan |
| author_sort | Yongxue Li |
| collection | DOAJ |
| description | Abstract Type 2 diabetes mellitus (T2DM) is a pivotal chronic disease with an increasing prevalence. Recent studies have found associations between T2DM and the development of central nervous system (CNS) tumours, a special class of solid tumours with an unclear pathogenesis. In this study, we aimed to explore the relationship between T2DM and certain glycaemic factors with common CNS tumours by using genetic data to conduct Mendelian randomization (MR) and co-localisation analysis. We found a causal relationship between T2DM and glioblastoma, fasting glucose and spinal cord tumours, glycated haemoglobin and spinal cord tumours, and insulin-like growth factor-1 and spinal cord tumours, pituitary tumours, and craniopharyngiomas. These results clarify the relationship between T2DM, glucose-related factors, and common CNS tumours, and they provide valuable insight into further clinical and basic research on CNS tumours, as well as new ideas for their diagnosis and treatment. |
| format | Article |
| id | doaj-art-e7e054bec7a74a63be341eaa8c3b8d83 |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-e7e054bec7a74a63be341eaa8c3b8d832024-12-01T12:32:14ZengBMCBMC Neurology1471-23772024-11-012411910.1186/s12883-024-03969-6Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous systemYongxue Li0Lihao Lin1Wenhui Zhang2Yan Wang3Yi Guan4Department of Neurosurgery, The First Hospital of Jilin UniversityDepartment of Neurosurgery, The First Hospital of Jilin UniversityDepartment of Neurosurgery, The Second Hospital of Tianjin Medical UniversityDepartment of Neurosurgery, The First Hospital of Jilin UniversityDepartment of Neurosurgery, The First Hospital of Jilin UniversityAbstract Type 2 diabetes mellitus (T2DM) is a pivotal chronic disease with an increasing prevalence. Recent studies have found associations between T2DM and the development of central nervous system (CNS) tumours, a special class of solid tumours with an unclear pathogenesis. In this study, we aimed to explore the relationship between T2DM and certain glycaemic factors with common CNS tumours by using genetic data to conduct Mendelian randomization (MR) and co-localisation analysis. We found a causal relationship between T2DM and glioblastoma, fasting glucose and spinal cord tumours, glycated haemoglobin and spinal cord tumours, and insulin-like growth factor-1 and spinal cord tumours, pituitary tumours, and craniopharyngiomas. These results clarify the relationship between T2DM, glucose-related factors, and common CNS tumours, and they provide valuable insight into further clinical and basic research on CNS tumours, as well as new ideas for their diagnosis and treatment.https://doi.org/10.1186/s12883-024-03969-6Type 2 diabetes mellitusFasting glucoseFasting insulinInsulin-like growth factor-1Glycated haemoglobinCentral nervous system tumours |
| spellingShingle | Yongxue Li Lihao Lin Wenhui Zhang Yan Wang Yi Guan Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system BMC Neurology Type 2 diabetes mellitus Fasting glucose Fasting insulin Insulin-like growth factor-1 Glycated haemoglobin Central nervous system tumours |
| title | Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system |
| title_full | Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system |
| title_fullStr | Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system |
| title_full_unstemmed | Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system |
| title_short | Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system |
| title_sort | genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system |
| topic | Type 2 diabetes mellitus Fasting glucose Fasting insulin Insulin-like growth factor-1 Glycated haemoglobin Central nervous system tumours |
| url | https://doi.org/10.1186/s12883-024-03969-6 |
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