Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity
Research investigating the effects of milk fat globule membranes (MFGM) on Salmonella typhimurium-induced colitis, intestinal barrier integrity, and gut-associated immune responses remains scarce. This study aimed to investigate the potential of dietary MFGM to alleviate S. typhimurium-induced colit...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Functional Foods |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624005358 |
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| author | Xiao Xiao Chen Ding Qianxu Wang Jiarui Zhao Qinyuan Bao Bingkun Bao Mengge Zhao Caroline Richard Zhigang Liu Yongbo She |
| author_facet | Xiao Xiao Chen Ding Qianxu Wang Jiarui Zhao Qinyuan Bao Bingkun Bao Mengge Zhao Caroline Richard Zhigang Liu Yongbo She |
| author_sort | Xiao Xiao |
| collection | DOAJ |
| description | Research investigating the effects of milk fat globule membranes (MFGM) on Salmonella typhimurium-induced colitis, intestinal barrier integrity, and gut-associated immune responses remains scarce. This study aimed to investigate the potential of dietary MFGM to alleviate S. typhimurium-induced colitis in mice. Male C57BL/6J mice were administered S. typhimurium to induce colitis and were then subjected to dietary interventions with either bovine MFGM (BMFGM) or goat MFGM (GMFGM). Both BMFGM and GMFGM mitigated S. typhimurium-induced colitis, as evidenced by increased body weight, decreased mRNA levels of pro-inflammatory cytokines (TNF-α, IFN-γ, IL-1β, and IL-6) in the colon, reduced intestinal permeability, and increased mRNA expression of tight junction-associated genes (Claudin-1 and ZO-1). Additionally, there was a reduction in the number of S. typhimurium in the mesenteric lymph nodes and an improvement in CD4 T cell activation status. Furthermore, liver and spleen injury was reduced, and serum levels of pro-inflammatory cytokines (IFN-γ, IL-1β, IL-4, IL-2, IL-6, and TNF-α) were decreased by both type of MFGM. Overall, BMFGM and GMFGM effectively alleviated S. typhimurium-induced colitis and associated hepatic and splenic injuries. |
| format | Article |
| id | doaj-art-e7ded23e9fe741249fa7f996834d31bd |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-e7ded23e9fe741249fa7f996834d31bd2024-11-16T05:10:50ZengElsevierJournal of Functional Foods1756-46462024-11-01122106533Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunityXiao Xiao0Chen Ding1Qianxu Wang2Jiarui Zhao3Qinyuan Bao4Bingkun Bao5Mengge Zhao6Caroline Richard7Zhigang Liu8Yongbo She9Division of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaDivision of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaDivision of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaDivision of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaDivision of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaDivision of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaDivision of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaDivision of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, CanadaDivision of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China; Shaanxi Precision Nutrition and Health Research Institute, Xi’an, Shaanxi, ChinaDivision of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada; Corresponding author at: Division of Food, Nutritional and Health Sciences, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi Province 712100, China.Research investigating the effects of milk fat globule membranes (MFGM) on Salmonella typhimurium-induced colitis, intestinal barrier integrity, and gut-associated immune responses remains scarce. This study aimed to investigate the potential of dietary MFGM to alleviate S. typhimurium-induced colitis in mice. Male C57BL/6J mice were administered S. typhimurium to induce colitis and were then subjected to dietary interventions with either bovine MFGM (BMFGM) or goat MFGM (GMFGM). Both BMFGM and GMFGM mitigated S. typhimurium-induced colitis, as evidenced by increased body weight, decreased mRNA levels of pro-inflammatory cytokines (TNF-α, IFN-γ, IL-1β, and IL-6) in the colon, reduced intestinal permeability, and increased mRNA expression of tight junction-associated genes (Claudin-1 and ZO-1). Additionally, there was a reduction in the number of S. typhimurium in the mesenteric lymph nodes and an improvement in CD4 T cell activation status. Furthermore, liver and spleen injury was reduced, and serum levels of pro-inflammatory cytokines (IFN-γ, IL-1β, IL-4, IL-2, IL-6, and TNF-α) were decreased by both type of MFGM. Overall, BMFGM and GMFGM effectively alleviated S. typhimurium-induced colitis and associated hepatic and splenic injuries.http://www.sciencedirect.com/science/article/pii/S1756464624005358 |
| spellingShingle | Xiao Xiao Chen Ding Qianxu Wang Jiarui Zhao Qinyuan Bao Bingkun Bao Mengge Zhao Caroline Richard Zhigang Liu Yongbo She Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity Journal of Functional Foods |
| title | Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity |
| title_full | Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity |
| title_fullStr | Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity |
| title_full_unstemmed | Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity |
| title_short | Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity |
| title_sort | milk fat globule membrane attenuates acute salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624005358 |
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