Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic Fields

<b>Background</b>: Inflammation is caused by an excess of Sodium ions inside the cell. This generates a variation in the cell’s membrane electric potential, becoming a steady state from a thermodynamic viewpoint. <b>Methods</b>: This paper introduces a thermodynamic approach...

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Main Authors: Umberto Lucia, Giulia Grisolia, Antonio Ponzetto, Thomas S. Deisboeck
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomedicines
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Online Access:https://www.mdpi.com/2227-9059/12/11/2534
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author Umberto Lucia
Giulia Grisolia
Antonio Ponzetto
Thomas S. Deisboeck
author_facet Umberto Lucia
Giulia Grisolia
Antonio Ponzetto
Thomas S. Deisboeck
author_sort Umberto Lucia
collection DOAJ
description <b>Background</b>: Inflammation is caused by an excess of Sodium ions inside the cell. This generates a variation in the cell’s membrane electric potential, becoming a steady state from a thermodynamic viewpoint. <b>Methods</b>: This paper introduces a thermodynamic approach to inflammation based on the fundamental role of the electric potential of the cell membrane, introducing an analysis of the effect of heat transfer related to the inflammation condition. <b>Results</b>: The direct proportionality between the reduction in temperature and the increase of Na<sup>+</sup> outflow may ameliorate the inflammation cascade. <b>Conclusions</b>: Based on these ion fluxes, we suggest the consideration of a ‘companion’ electromagnetic therapeutic wave concept in support of the present anti-inflammatory treatment.
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series Biomedicines
spelling doaj-art-e7da5178fe09441d81c5656da30522ba2024-11-26T17:53:08ZengMDPI AGBiomedicines2227-90592024-11-011211253410.3390/biomedicines12112534Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic FieldsUmberto Lucia0Giulia Grisolia1Antonio Ponzetto2Thomas S. Deisboeck3Dipartimento Energia “Galileo Ferraris”, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, ItalyDipartimento di Ingegneria dell’Ambiente, del Territorio e delle Infrastrutture, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, ItalyDipartimento di Scienze Mediche, Università di Torino, Corso Dogliotti 14, 10126 Torino, ItalyDepartment of Radiology, Harvard-MIT Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA<b>Background</b>: Inflammation is caused by an excess of Sodium ions inside the cell. This generates a variation in the cell’s membrane electric potential, becoming a steady state from a thermodynamic viewpoint. <b>Methods</b>: This paper introduces a thermodynamic approach to inflammation based on the fundamental role of the electric potential of the cell membrane, introducing an analysis of the effect of heat transfer related to the inflammation condition. <b>Results</b>: The direct proportionality between the reduction in temperature and the increase of Na<sup>+</sup> outflow may ameliorate the inflammation cascade. <b>Conclusions</b>: Based on these ion fluxes, we suggest the consideration of a ‘companion’ electromagnetic therapeutic wave concept in support of the present anti-inflammatory treatment.https://www.mdpi.com/2227-9059/12/11/2534inflammationELF-EMFion fluxesthermodynamics of biosystemsbiomagnetismmembrane potential
spellingShingle Umberto Lucia
Giulia Grisolia
Antonio Ponzetto
Thomas S. Deisboeck
Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic Fields
Biomedicines
inflammation
ELF-EMF
ion fluxes
thermodynamics of biosystems
biomagnetism
membrane potential
title Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic Fields
title_full Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic Fields
title_fullStr Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic Fields
title_full_unstemmed Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic Fields
title_short Thermophysical Insights into the Anti-Inflammatory Potential of Magnetic Fields
title_sort thermophysical insights into the anti inflammatory potential of magnetic fields
topic inflammation
ELF-EMF
ion fluxes
thermodynamics of biosystems
biomagnetism
membrane potential
url https://www.mdpi.com/2227-9059/12/11/2534
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AT giuliagrisolia thermophysicalinsightsintotheantiinflammatorypotentialofmagneticfields
AT antonioponzetto thermophysicalinsightsintotheantiinflammatorypotentialofmagneticfields
AT thomassdeisboeck thermophysicalinsightsintotheantiinflammatorypotentialofmagneticfields