Potential predictor of prognosis in breast carcinoma: Tumor budding
Background: Breast cancer is the most common cancer in women, with invasive breast carcinoma of no special type (IBC-NST) accounting for the majority of cases. Aim: This study aimed to evaluate the relationship between tumor budding (TB), which is the earliest histological indicator of tumor spread...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_300_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849243500103598080 |
|---|---|
| author | İnci Usta Tülin D. Yalta Nuray Can Necdet Süt Ebru Taştekin Fulya Ö. Puyan Ufuk Usta Ezgi G. Erdoğan Elif M. Demirtaş Merve Bağış Erkan Özcan İrfan Çiçin |
| author_facet | İnci Usta Tülin D. Yalta Nuray Can Necdet Süt Ebru Taştekin Fulya Ö. Puyan Ufuk Usta Ezgi G. Erdoğan Elif M. Demirtaş Merve Bağış Erkan Özcan İrfan Çiçin |
| author_sort | İnci Usta |
| collection | DOAJ |
| description | Background:
Breast cancer is the most common cancer in women, with invasive breast carcinoma of no special type (IBC-NST) accounting for the majority of cases.
Aim:
This study aimed to evaluate the relationship between tumor budding (TB), which is the earliest histological indicator of tumor spread and represents epithelial–mesenchymal transition, and prognostic factors as well as the effect of TB on survival in patients with IBC-NST, thereby demonstrating its potential prognostic value.
Materials and Methods:
This study included 278 cases of breast resection diagnosed with IBC-NST from 2014 to 2019. Total tumor buds were counted in 10 high-power fields of a hematoxylin and eosin–stained section with the most infiltrative area at 400× magnification. The cutoff value for TB was obtained using receiver operating characteristic analysis for mortality and recurrence risk; this cutoff value was used to classify TB into two categories: low and high grades. The relationship between TB and prognostic factors and the effect of TB on the survival of patients were investigated.
Results:
This study revealed a statistically significant relationship between high-grade TB and increased tumor size, advanced pathological primary tumor (pT) category, lymph node metastasis, lymphatic invasion, blood vessel invasion, increased recurrence, and mortality as well as reduced overall and disease-free survival.
Conclusion:
TB in breast carcinomas may have significant predictive value for prognosis. It emerges as a simple, reproducible, and cost-effective histological marker. With the standardization of evaluation criteria, TB may be readily integrated into routine pathological examination, thereby increasing its value in clinical patient management. |
| format | Article |
| id | doaj-art-e7d64b8420674c289a8ba8b8e9538a4a |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-e7d64b8420674c289a8ba8b8e9538a4a2025-08-20T03:59:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302025-04-0168231732310.4103/ijpm.ijpm_300_24Potential predictor of prognosis in breast carcinoma: Tumor buddingİnci UstaTülin D. YaltaNuray CanNecdet SütEbru TaştekinFulya Ö. PuyanUfuk UstaEzgi G. ErdoğanElif M. DemirtaşMerve BağışErkan Özcanİrfan ÇiçinBackground: Breast cancer is the most common cancer in women, with invasive breast carcinoma of no special type (IBC-NST) accounting for the majority of cases. Aim: This study aimed to evaluate the relationship between tumor budding (TB), which is the earliest histological indicator of tumor spread and represents epithelial–mesenchymal transition, and prognostic factors as well as the effect of TB on survival in patients with IBC-NST, thereby demonstrating its potential prognostic value. Materials and Methods: This study included 278 cases of breast resection diagnosed with IBC-NST from 2014 to 2019. Total tumor buds were counted in 10 high-power fields of a hematoxylin and eosin–stained section with the most infiltrative area at 400× magnification. The cutoff value for TB was obtained using receiver operating characteristic analysis for mortality and recurrence risk; this cutoff value was used to classify TB into two categories: low and high grades. The relationship between TB and prognostic factors and the effect of TB on the survival of patients were investigated. Results: This study revealed a statistically significant relationship between high-grade TB and increased tumor size, advanced pathological primary tumor (pT) category, lymph node metastasis, lymphatic invasion, blood vessel invasion, increased recurrence, and mortality as well as reduced overall and disease-free survival. Conclusion: TB in breast carcinomas may have significant predictive value for prognosis. It emerges as a simple, reproducible, and cost-effective histological marker. With the standardization of evaluation criteria, TB may be readily integrated into routine pathological examination, thereby increasing its value in clinical patient management.https://journals.lww.com/10.4103/ijpm.ijpm_300_24epithelial–mesenchymal transitioninvasive breast carcinomaprognostic factortumor budding |
| spellingShingle | İnci Usta Tülin D. Yalta Nuray Can Necdet Süt Ebru Taştekin Fulya Ö. Puyan Ufuk Usta Ezgi G. Erdoğan Elif M. Demirtaş Merve Bağış Erkan Özcan İrfan Çiçin Potential predictor of prognosis in breast carcinoma: Tumor budding Indian Journal of Pathology and Microbiology epithelial–mesenchymal transition invasive breast carcinoma prognostic factor tumor budding |
| title | Potential predictor of prognosis in breast carcinoma: Tumor budding |
| title_full | Potential predictor of prognosis in breast carcinoma: Tumor budding |
| title_fullStr | Potential predictor of prognosis in breast carcinoma: Tumor budding |
| title_full_unstemmed | Potential predictor of prognosis in breast carcinoma: Tumor budding |
| title_short | Potential predictor of prognosis in breast carcinoma: Tumor budding |
| title_sort | potential predictor of prognosis in breast carcinoma tumor budding |
| topic | epithelial–mesenchymal transition invasive breast carcinoma prognostic factor tumor budding |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_300_24 |
| work_keys_str_mv | AT inciusta potentialpredictorofprognosisinbreastcarcinomatumorbudding AT tulindyalta potentialpredictorofprognosisinbreastcarcinomatumorbudding AT nuraycan potentialpredictorofprognosisinbreastcarcinomatumorbudding AT necdetsut potentialpredictorofprognosisinbreastcarcinomatumorbudding AT ebrutastekin potentialpredictorofprognosisinbreastcarcinomatumorbudding AT fulyaopuyan potentialpredictorofprognosisinbreastcarcinomatumorbudding AT ufukusta potentialpredictorofprognosisinbreastcarcinomatumorbudding AT ezgigerdogan potentialpredictorofprognosisinbreastcarcinomatumorbudding AT elifmdemirtas potentialpredictorofprognosisinbreastcarcinomatumorbudding AT mervebagıs potentialpredictorofprognosisinbreastcarcinomatumorbudding AT erkanozcan potentialpredictorofprognosisinbreastcarcinomatumorbudding AT irfancicin potentialpredictorofprognosisinbreastcarcinomatumorbudding |