Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification
The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [ 11 C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-06-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2012.00040 |
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| _version_ | 1841563181802061824 |
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| author | Èlia Torrent Magí Farré Ibane Abasolo Olga Millan Jordi LLop Juan Domingo Gispert Alba Ruiz Deborah Pareto |
| author_facet | Èlia Torrent Magí Farré Ibane Abasolo Olga Millan Jordi LLop Juan Domingo Gispert Alba Ruiz Deborah Pareto |
| author_sort | Èlia Torrent |
| collection | DOAJ |
| description | The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [ 11 C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two rat data sets: a baseline versus a pretreatment study (with cold raclopride) and a young versus an old animal group comparison. The study results support the contention that optimization of [ 11 C]raclopride positron emission tomographic studies in rats by shortening the acquisition time is feasible. In addition, filtered backprojection is recommended as a reconstruction algorithm, although iterative methods may be more sensitive to detect within-group differences. |
| format | Article |
| id | doaj-art-e7d24bcb5b264fc882c1c464b3500886 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2013-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-e7d24bcb5b264fc882c1c464b35008862025-01-03T00:11:15ZengSAGE PublishingMolecular Imaging1536-01212013-06-011210.2310/7290.2012.0004010.2310_7290.2012.00040Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image QuantificationÈlia TorrentMagí FarréIbane AbasoloOlga MillanJordi LLopJuan Domingo GispertAlba RuizDeborah ParetoThe goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [ 11 C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two rat data sets: a baseline versus a pretreatment study (with cold raclopride) and a young versus an old animal group comparison. The study results support the contention that optimization of [ 11 C]raclopride positron emission tomographic studies in rats by shortening the acquisition time is feasible. In addition, filtered backprojection is recommended as a reconstruction algorithm, although iterative methods may be more sensitive to detect within-group differences.https://doi.org/10.2310/7290.2012.00040 |
| spellingShingle | Èlia Torrent Magí Farré Ibane Abasolo Olga Millan Jordi LLop Juan Domingo Gispert Alba Ruiz Deborah Pareto Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification Molecular Imaging |
| title | Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification |
| title_full | Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification |
| title_fullStr | Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification |
| title_full_unstemmed | Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification |
| title_short | Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification |
| title_sort | optimization of c raclopride positron emission tomographic rat studies comparison of methods for image quantification |
| url | https://doi.org/10.2310/7290.2012.00040 |
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