Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders
IntroductionSalivary Lactate Dehydrogenase (sLDH) levels seem to be higher in patients with Oral Squamous Cell Carcinoma (OSCC) and Oral Potentially Malignant Disorders (OPMD) than a control group (CG).MethodsCase-control study. Patients with OPMD [oral leukoplakia (OL) and oral lichen planus (OLP)]...
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Frontiers Media S.A.
2025-01-01
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| author | Rosa María López-Pintor Rosa María López-Pintor José González-Serrano José González-Serrano Carmen Vallina Katerina Ivaylova Serkedzhieva Katerina Ivaylova Serkedzhieva Leire Virto Paula Nuevo Vito Carlo Alberto Caponio Vito Carlo Alberto Caponio Margarita Iniesta Tania Rodríguez Santamarta Paloma Lequerica Fernández Óscar Iglesias Velázquez Óscar Iglesias Velázquez Gonzalo Hernández Gonzalo Hernández Juan Carlos de Vicente Juan Carlos de Vicente |
| author_facet | Rosa María López-Pintor Rosa María López-Pintor José González-Serrano José González-Serrano Carmen Vallina Katerina Ivaylova Serkedzhieva Katerina Ivaylova Serkedzhieva Leire Virto Paula Nuevo Vito Carlo Alberto Caponio Vito Carlo Alberto Caponio Margarita Iniesta Tania Rodríguez Santamarta Paloma Lequerica Fernández Óscar Iglesias Velázquez Óscar Iglesias Velázquez Gonzalo Hernández Gonzalo Hernández Juan Carlos de Vicente Juan Carlos de Vicente |
| author_sort | Rosa María López-Pintor |
| collection | DOAJ |
| description | IntroductionSalivary Lactate Dehydrogenase (sLDH) levels seem to be higher in patients with Oral Squamous Cell Carcinoma (OSCC) and Oral Potentially Malignant Disorders (OPMD) than a control group (CG).MethodsCase-control study. Patients with OPMD [oral leukoplakia (OL) and oral lichen planus (OLP)] and OSCC who attended two services in Spain were selected. sLDH in saliva was measured. Epidemiological, periodontal and specific variables related to OPMD and OSCC were collected.ResultsA total of 92 patients were included: 12 with OSCC, 51 with OPMD (17 OL and 34 OLP), and 29 controls. sLDH values were higher in the OSCC, followed by the OPMD and CG groups, although no significant differences were observed. In the OSCC group, larger tumor size was associated with higher sLDH levels. In the OLP group, sLDH values were higher in patients with symptomatic lesions than in patients with only white lesions, but not significantly. No associations were observed between sLDH and the type of OL (homogeneous vs. non-homogeneous) and the degree of dysplasia. When analyzing periodontal variables among OSCC, OPMD and CG, periodontal probing depth (PPD) and bleeding on probing were significantly higher in the OSCC group, while the plaque index was higher in OPMD patients. The linear regression model for sLDH in the total group identified age and PPD as significant predictors of sLDH levels.DiscussionAlthough sLDH values were higher in OSCC and OPMD patients than in a CG, the results do not support the use of sLDH as a reliable prognostic biomarker of malignancy. Future studies need to consider other factors that may influence sLDH levels, such as age and periodontal status. |
| format | Article |
| id | doaj-art-e7ba1d1305a14523a544f95caf24c70c |
| institution | Kabale University |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oral Health |
| spelling | doaj-art-e7ba1d1305a14523a544f95caf24c70c2025-01-07T06:48:02ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-01-01510.3389/froh.2024.15259361525936Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disordersRosa María López-Pintor0Rosa María López-Pintor1José González-Serrano2José González-Serrano3Carmen Vallina4Katerina Ivaylova Serkedzhieva5Katerina Ivaylova Serkedzhieva6Leire Virto7Paula Nuevo8Vito Carlo Alberto Caponio9Vito Carlo Alberto Caponio10Margarita Iniesta11Tania Rodríguez Santamarta12Paloma Lequerica Fernández13Óscar Iglesias Velázquez14Óscar Iglesias Velázquez15Gonzalo Hernández16Gonzalo Hernández17Juan Carlos de Vicente18Juan Carlos de Vicente19Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University, Madrid, SpainORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University, Madrid, SpainORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University, Madrid, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University, Madrid, SpainORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, SpainDepartment of Anatomy and Embryology, Faculty of Optics and Optometry, Complutense University, Madrid, SpainResearch Laboratory, Faculty of Dentistry, Complutense University, Madrid, SpainORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, SpainDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University, Madrid, SpainDepartment of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, SpainDepartment of Biochemistry, Hospital Universitario Central de Asturias (HUCA), Oviedo, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University, Madrid, SpainORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University, Madrid, SpainORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, SpainORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, SpainDepartment of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, SpainIntroductionSalivary Lactate Dehydrogenase (sLDH) levels seem to be higher in patients with Oral Squamous Cell Carcinoma (OSCC) and Oral Potentially Malignant Disorders (OPMD) than a control group (CG).MethodsCase-control study. Patients with OPMD [oral leukoplakia (OL) and oral lichen planus (OLP)] and OSCC who attended two services in Spain were selected. sLDH in saliva was measured. Epidemiological, periodontal and specific variables related to OPMD and OSCC were collected.ResultsA total of 92 patients were included: 12 with OSCC, 51 with OPMD (17 OL and 34 OLP), and 29 controls. sLDH values were higher in the OSCC, followed by the OPMD and CG groups, although no significant differences were observed. In the OSCC group, larger tumor size was associated with higher sLDH levels. In the OLP group, sLDH values were higher in patients with symptomatic lesions than in patients with only white lesions, but not significantly. No associations were observed between sLDH and the type of OL (homogeneous vs. non-homogeneous) and the degree of dysplasia. When analyzing periodontal variables among OSCC, OPMD and CG, periodontal probing depth (PPD) and bleeding on probing were significantly higher in the OSCC group, while the plaque index was higher in OPMD patients. The linear regression model for sLDH in the total group identified age and PPD as significant predictors of sLDH levels.DiscussionAlthough sLDH values were higher in OSCC and OPMD patients than in a CG, the results do not support the use of sLDH as a reliable prognostic biomarker of malignancy. Future studies need to consider other factors that may influence sLDH levels, such as age and periodontal status.https://www.frontiersin.org/articles/10.3389/froh.2024.1525936/fullL-Lactate dehydrogenasesalivabiomarkersoral squamous cell carcinomamouth neoplasmsoral leukoplakia |
| spellingShingle | Rosa María López-Pintor Rosa María López-Pintor José González-Serrano José González-Serrano Carmen Vallina Katerina Ivaylova Serkedzhieva Katerina Ivaylova Serkedzhieva Leire Virto Paula Nuevo Vito Carlo Alberto Caponio Vito Carlo Alberto Caponio Margarita Iniesta Tania Rodríguez Santamarta Paloma Lequerica Fernández Óscar Iglesias Velázquez Óscar Iglesias Velázquez Gonzalo Hernández Gonzalo Hernández Juan Carlos de Vicente Juan Carlos de Vicente Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders Frontiers in Oral Health L-Lactate dehydrogenase saliva biomarkers oral squamous cell carcinoma mouth neoplasms oral leukoplakia |
| title | Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders |
| title_full | Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders |
| title_fullStr | Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders |
| title_full_unstemmed | Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders |
| title_short | Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders |
| title_sort | factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders |
| topic | L-Lactate dehydrogenase saliva biomarkers oral squamous cell carcinoma mouth neoplasms oral leukoplakia |
| url | https://www.frontiersin.org/articles/10.3389/froh.2024.1525936/full |
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