Mechanism of myocardial mitochondrial injury in sepsis
Sepsis and infectious shock remain the leading causes of death in critically ill patients. Despite the adoption of various treatment strategies to date, the outcomeshave been suboptimal. Sepsis-induced myocardial dysfunction (SIMD) is a common complication of severe sepsis. It is one of the leading...
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The Editorial Department of Chinese Journal of Clinical Research
2024-12-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241224 |
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| _version_ | 1846100491001397248 |
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| author | WANG Si, ZHANG Pan, XIE Junmin |
| author_facet | WANG Si, ZHANG Pan, XIE Junmin |
| author_sort | WANG Si, ZHANG Pan, XIE Junmin |
| collection | DOAJ |
| description | Sepsis and infectious shock remain the leading causes of death in critically ill patients. Despite the adoption of various treatment strategies to date, the outcomeshave been suboptimal. Sepsis-induced myocardial dysfunction (SIMD) is a common complication of severe sepsis. It is one of the leading causes of death. Therefore, further understanding of SIMD is very important for the treatment of sepsis. Mitochondria, as the main sites of energy metabolism of cardiomyocytes, play an important role in structural abnormalities and dysfunction. Mitochondrial dysfunction mainly includes oxidative stress, mitochondrial uncoupling, disturbance of mitochondrial quality control system, Ca2+ overload and altered mitochondrial membrane permeability.
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| format | Article |
| id | doaj-art-e7b91f4d0a48484cb3a7b409f0d488fb |
| institution | Kabale University |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-e7b91f4d0a48484cb3a7b409f0d488fb2024-12-30T07:22:48ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822024-12-0137121936193910.13429/j.cnki.cjcr.2024.12.024Mechanism of myocardial mitochondrial injury in sepsisWANG Si, ZHANG Pan, XIE Junmin0Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, ChinaSepsis and infectious shock remain the leading causes of death in critically ill patients. Despite the adoption of various treatment strategies to date, the outcomeshave been suboptimal. Sepsis-induced myocardial dysfunction (SIMD) is a common complication of severe sepsis. It is one of the leading causes of death. Therefore, further understanding of SIMD is very important for the treatment of sepsis. Mitochondria, as the main sites of energy metabolism of cardiomyocytes, play an important role in structural abnormalities and dysfunction. Mitochondrial dysfunction mainly includes oxidative stress, mitochondrial uncoupling, disturbance of mitochondrial quality control system, Ca2+ overload and altered mitochondrial membrane permeability. http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241224sepsismitochondrioncardiac dysfunctionoxidative stresscalcium overloadmitochondrial quality control |
| spellingShingle | WANG Si, ZHANG Pan, XIE Junmin Mechanism of myocardial mitochondrial injury in sepsis Zhongguo linchuang yanjiu sepsis mitochondrion cardiac dysfunction oxidative stress calcium overload mitochondrial quality control |
| title | Mechanism of myocardial mitochondrial injury in sepsis |
| title_full | Mechanism of myocardial mitochondrial injury in sepsis |
| title_fullStr | Mechanism of myocardial mitochondrial injury in sepsis |
| title_full_unstemmed | Mechanism of myocardial mitochondrial injury in sepsis |
| title_short | Mechanism of myocardial mitochondrial injury in sepsis |
| title_sort | mechanism of myocardial mitochondrial injury in sepsis |
| topic | sepsis mitochondrion cardiac dysfunction oxidative stress calcium overload mitochondrial quality control |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241224 |
| work_keys_str_mv | AT wangsizhangpanxiejunmin mechanismofmyocardialmitochondrialinjuryinsepsis |