Iron metabolism and ferroptosis in human health and disease
Abstract Iron is indispensable to most lifeforms, underpinning a myriad of physiological processes. Dysregulation of iron homeostasis underlies a broad spectrum of biological phenomena and pathological conditions. Notably, excessive iron overload acts as a key driver of ferroptosis, a unique form of...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | BMC Biology |
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| Online Access: | https://doi.org/10.1186/s12915-025-02378-6 |
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| author | Meijuan Zhong Yuandi Wang Junxia Min Fudi Wang |
| author_facet | Meijuan Zhong Yuandi Wang Junxia Min Fudi Wang |
| author_sort | Meijuan Zhong |
| collection | DOAJ |
| description | Abstract Iron is indispensable to most lifeforms, underpinning a myriad of physiological processes. Dysregulation of iron homeostasis underlies a broad spectrum of biological phenomena and pathological conditions. Notably, excessive iron overload acts as a key driver of ferroptosis, a unique form of regulated cell death. Consequently, through the lens of ferrology, targeted modulation of iron balance and ferroptosis has emerged as a compelling avenue for the prevention and treatment of major diseases. Herein, we review the molecular mechanisms governing iron homeostasis, the roles of iron metabolism disorders and ferroptosis in disease pathogenesis, and the latest breakthroughs in iron-regulated therapeutic agents. |
| format | Article |
| id | doaj-art-e7b5d789fa3342c4b3963c5bdd8ada93 |
| institution | Kabale University |
| issn | 1741-7007 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-e7b5d789fa3342c4b3963c5bdd8ada932025-08-24T11:50:25ZengBMCBMC Biology1741-70072025-08-0123111610.1186/s12915-025-02378-6Iron metabolism and ferroptosis in human health and diseaseMeijuan Zhong0Yuandi Wang1Junxia Min2Fudi Wang3School of Public Health, Hengyang Medical School, University of South ChinaSchool of Public Health, Hengyang Medical School, University of South ChinaInstitute of Translational Medicine, The First Affiliated Hospital, Zhejiang University School of MedicineSchool of Public Health, Hengyang Medical School, University of South ChinaAbstract Iron is indispensable to most lifeforms, underpinning a myriad of physiological processes. Dysregulation of iron homeostasis underlies a broad spectrum of biological phenomena and pathological conditions. Notably, excessive iron overload acts as a key driver of ferroptosis, a unique form of regulated cell death. Consequently, through the lens of ferrology, targeted modulation of iron balance and ferroptosis has emerged as a compelling avenue for the prevention and treatment of major diseases. Herein, we review the molecular mechanisms governing iron homeostasis, the roles of iron metabolism disorders and ferroptosis in disease pathogenesis, and the latest breakthroughs in iron-regulated therapeutic agents.https://doi.org/10.1186/s12915-025-02378-6Iron homeostasisFerroptosisIron supplementationFerrology |
| spellingShingle | Meijuan Zhong Yuandi Wang Junxia Min Fudi Wang Iron metabolism and ferroptosis in human health and disease BMC Biology Iron homeostasis Ferroptosis Iron supplementation Ferrology |
| title | Iron metabolism and ferroptosis in human health and disease |
| title_full | Iron metabolism and ferroptosis in human health and disease |
| title_fullStr | Iron metabolism and ferroptosis in human health and disease |
| title_full_unstemmed | Iron metabolism and ferroptosis in human health and disease |
| title_short | Iron metabolism and ferroptosis in human health and disease |
| title_sort | iron metabolism and ferroptosis in human health and disease |
| topic | Iron homeostasis Ferroptosis Iron supplementation Ferrology |
| url | https://doi.org/10.1186/s12915-025-02378-6 |
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