Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease
Abstract The long-term hypercortisolemia of Cushing disease (CD) may lead to hemodynamic disorders by increasing subclinical cardiac and vascular dysfunction. The purpose of this observational cohort study was to assess the relationship between hemodynamic parameters evaluated via impedance cardiogr...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84888-x |
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| author | Agnieszka Włochacz Paweł Krzesiński Beata Uziębło-Życzkowska Przemysław Witek Grzegorz Zieliński Anna Kazimierczak Robert Wierzbowski Małgorzata Banak Grzegorz Gielerak |
| author_facet | Agnieszka Włochacz Paweł Krzesiński Beata Uziębło-Życzkowska Przemysław Witek Grzegorz Zieliński Anna Kazimierczak Robert Wierzbowski Małgorzata Banak Grzegorz Gielerak |
| author_sort | Agnieszka Włochacz |
| collection | DOAJ |
| description | Abstract The long-term hypercortisolemia of Cushing disease (CD) may lead to hemodynamic disorders by increasing subclinical cardiac and vascular dysfunction. The purpose of this observational cohort study was to assess the relationship between hemodynamic parameters evaluated via impedance cardiography (ICG) and echocardiographic parameters reflecting left ventricular function in 54 patients newly diagnosed with CD. The parameters assessed via ICG included stroke volume index (SI), cardiac index (CI), acceleration index (ACI), velocity index (VI), systemic vascular resistance index (SVRI), total artery compliance index (TACI). The echocardiographic parameters included left ventricular mass index (LVMI) and left ventricular systolic and diastolic parameters. Higher LVMI values were associated with lower SI (p = 0.003), CI (p = 0.001), VI (p = 0.048), TACI (p < 0.001), and with higher SVRI (p < 0.001). Poorer parameters of left ventricular diastolic function corresponded to the parameters assessed via ICG: (1) lower ratio E/A was associated with lower SI (p = 0.002), VI (p = 0.001), ACI (p = 0.01), TACI (p = 0.001); (2) lower average e’ was associated with lower SI (p = 0.017), CI (p = 0.009), VI (p = 0.004), TACI (p = 0.001), and with higher SVRI (p = 0.002); (3) higher ratio E/e’ corresponded to lower TACI (p = 0.01). Decreased global longitudinal strain corresponded to lower TACI (p = 0.046). CD is associated with impaired pumping function of the heart and higher afterload. |
| format | Article |
| id | doaj-art-e7af6c321d434933bef622519ba92f54 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e7af6c321d434933bef622519ba92f542025-01-05T12:23:23ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-84888-xImpaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing diseaseAgnieszka Włochacz0Paweł Krzesiński1Beata Uziębło-Życzkowska2Przemysław Witek3Grzegorz Zieliński4Anna Kazimierczak5Robert Wierzbowski6Małgorzata Banak7Grzegorz Gielerak8Department of Cardiology and Internal Medicine, Military Institute of Medicine – National Research InstituteDepartment of Cardiology and Internal Medicine, Military Institute of Medicine – National Research InstituteDepartment of Cardiology and Internal Medicine, Military Institute of Medicine – National Research InstituteDepartment of Internal Medicine and Endocrinology, Medical University of WarsawDepartment of Neurosurgery, Military Institute of Medicine – National Research InstituteDepartment of Cardiology and Internal Medicine, Military Institute of Medicine – National Research InstituteDepartment of Cardiology and Internal Medicine, Military Institute of Medicine – National Research InstituteDepartment of Cardiology and Internal Medicine, Military Institute of Medicine – National Research InstituteDepartment of Cardiology and Internal Medicine, Military Institute of Medicine – National Research InstituteAbstract The long-term hypercortisolemia of Cushing disease (CD) may lead to hemodynamic disorders by increasing subclinical cardiac and vascular dysfunction. The purpose of this observational cohort study was to assess the relationship between hemodynamic parameters evaluated via impedance cardiography (ICG) and echocardiographic parameters reflecting left ventricular function in 54 patients newly diagnosed with CD. The parameters assessed via ICG included stroke volume index (SI), cardiac index (CI), acceleration index (ACI), velocity index (VI), systemic vascular resistance index (SVRI), total artery compliance index (TACI). The echocardiographic parameters included left ventricular mass index (LVMI) and left ventricular systolic and diastolic parameters. Higher LVMI values were associated with lower SI (p = 0.003), CI (p = 0.001), VI (p = 0.048), TACI (p < 0.001), and with higher SVRI (p < 0.001). Poorer parameters of left ventricular diastolic function corresponded to the parameters assessed via ICG: (1) lower ratio E/A was associated with lower SI (p = 0.002), VI (p = 0.001), ACI (p = 0.01), TACI (p = 0.001); (2) lower average e’ was associated with lower SI (p = 0.017), CI (p = 0.009), VI (p = 0.004), TACI (p = 0.001), and with higher SVRI (p = 0.002); (3) higher ratio E/e’ corresponded to lower TACI (p = 0.01). Decreased global longitudinal strain corresponded to lower TACI (p = 0.046). CD is associated with impaired pumping function of the heart and higher afterload.https://doi.org/10.1038/s41598-024-84888-xCushing diseaseEchocardiographyGlobal longitudinal strainHemodynamic disordersImpedance cardiographyPituitary neuroendocrine tumor |
| spellingShingle | Agnieszka Włochacz Paweł Krzesiński Beata Uziębło-Życzkowska Przemysław Witek Grzegorz Zieliński Anna Kazimierczak Robert Wierzbowski Małgorzata Banak Grzegorz Gielerak Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease Scientific Reports Cushing disease Echocardiography Global longitudinal strain Hemodynamic disorders Impedance cardiography Pituitary neuroendocrine tumor |
| title | Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease |
| title_full | Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease |
| title_fullStr | Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease |
| title_full_unstemmed | Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease |
| title_short | Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease |
| title_sort | impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in cushing disease |
| topic | Cushing disease Echocardiography Global longitudinal strain Hemodynamic disorders Impedance cardiography Pituitary neuroendocrine tumor |
| url | https://doi.org/10.1038/s41598-024-84888-x |
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