Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis

Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis

BackgroundNeoadjuvant immunotherapy (NIT) has been endorsed by clinical guidelines for the management of DNA mismatch repair deficiency/microsatellite instability-high (dMMR/MSI-H) locally advanced rectal cancer (LARC). Nonetheless, the therapeutic efficacy of NIT in mismatch repair-proficient/micro...

Full description

Saved in:

Bibliographic Details
Main Authors:	Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Liyan Zhou, Jianxin Xue, Min Ren
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Immunology
Subjects:	neoadjuvant immunotherapy non-metastatic rectal cancer mismatch repair-proficient/microsatellite stable meta-analysis efficacy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523455/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Impact on CD4+ CD25High-CD127low regulatory T (Treg) cells of neoadjuvant therapy for rectal cancer patients
by: Liu Maoxi, et al.
Published: (2023-07-01)

Role of mast cell in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
by: Masaaki Nishi, et al.
Published: (2025-01-01)

Computed Tomography Scan and Clinical-based Complete Response Prediction in Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiotherapy: A Machine Learning Approach
by: Seyyed Hossein Mousavie Anijdan, et al.
Published: (2024-12-01)

The characteristics of the tumor immune microenvironment in colorectal cancer with different MSI status and current therapeutic strategies
by: Qingzhe Wang, et al.
Published: (2025-01-01)

Organ Function Preservation in Locally Advanced Low Rectal Cancer Through Total Neoadjuvant Therapy: A Case Report and Literature Review
by: Liu F, et al.
Published: (2025-01-01)

Prognostic Value of Tumor Regression Grade Combined with Pathological Lymph Node Status in Initially Node-Positive Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy
by: Dakui Luo, et al.
Published: (2025-01-01)

Radiomics in rectal cancer: current status of use and advances in research
by: Wei-Qin Huang, et al.
Published: (2025-01-01)

A management of patients achieving clinical complete response after neoadjuvant therapy and perspectives: on locally advanced rectal cancer
by: Yu-Xin Liu, et al.
Published: (2025-01-01)

Comparison of prognosis for T4b rectal cancer with different pelvic compartment involvement treated using neoadjuvant chemoradiotherapy and implications for refinement of the current T staging system: A retrospective cohort study
by: Yang-zi Zhang, et al.
Published: (2025-03-01)

How Do MRI Findings Influence Rectal Cancer Management?
by: Ayloor Seshadri Ramakrishnan, et al.

Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis of randomized controlled trials
by: Wenji Pu, et al.
Published: (2024-12-01)

Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer
by: Chien-Tzu Huang*, et al.
Published: (2023-07-01)

Corrigendum: Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis of randomized controlled trials
by: Wenji Pu, et al.
Published: (2025-01-01)

Organ preservation strategies for rectal cancer treatment: tarts or trap?
by: ZHOU Yihang, ZENG Ziwei, KANG Liang
Published: (2024-09-01)

Durable Clinical Benefit after Dual Checkpoint Inhibition and Single-agent Nivolumab Following Pembrolizumab Failure in Mismatch Repair-deficient Colon Cancer
by: Yat-Fung Chow, et al.
Published: (2023-10-01)

HIGH-PROFICIENCY AND LOW-PROFICIENCY LEARNERS’ COMPENSATION STRATEGIES USE IN ENGLISH LANGUAGE LEARNING
by: Tania Tahmina
Published: (2024-12-01)

DMMR status and synchronous lesions predicts metachronous lesions after curative resection for rectal cancer
by: Xijie Chen, et al.
Published: (2025-01-01)

INFLUENCE OF MATERIAL PARAMETER MISMATCH ON CRACK PROPAGATION IN COMPOSITE LAMINATES
by: LI YouTang, et al.
Published: (2022-01-01)

Genomic microsatellite characterization and development of polymorphic microsatellites in Eospalax baileyi
by: Qiqi Hou, et al.
Published: (2025-01-01)

Microsatellite analyses reveal genetic diversity and population structure of Cipangopaludina chinensis in Guangxi, China
by: Xiao-kai Wei, et al.
Published: (2025-03-01)

Digital rural construction, resource mismatch, and rural land use efficiency
by: Zhiguo Fan, et al.
Published: (2025-02-01)

Analysis of Spatial Mismatch of Job and Residence in 22 Regions of Tehran Municipality
by: Tajeddin Karami, et al.
Published: (2024-06-01)

Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability
by: Miguel A. Gómez-Álvarez, et al.
Published: (2016-12-01)

NEWSPAPERS EFFECT ON STUDENTS’ WRITING ACHIEVEMENT ACROSS ENGLISH PROFICIENCY LEVELS
by: Rizky Amelia, et al.
Published: (2021-02-01)

The pattern of genetic diversity of different breeds of pigs based on microsatellite analysis
by: V. R. Kharzinova, et al.
Published: (2020-12-01)

A general modular scoring system for evaluating proficiency levels of a surgery
by: Jin Li, et al.
Published: (2025-02-01)

Breast Cancer: Neoadjuvant Chemotherapy
by: Barbara F. Shea, et al.
Published: (2015-05-01)

Breast Cancer: Neoadjuvant Chemotherapy
by: Barbara F. Shea, et al.
Published: (2015-05-01)

A combined diagnostic model including middle rectal artery visualization for predicting lateral lymph node metastasis in rectal cancer
by: Ning Wang, et al.
Published: (2025-01-01)

Complete Rectal Prolapse. Case presentation
by: José Antonio Feliu Rosa, et al.
Published: (2017-10-01)

E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age
by: E. Meldolesi, et al.
Published: (2025-03-01)

Analysis of genetic structures of hasmer, hasak and german black head sheep breeds by using microsatellite markers
by: Zafer Bulut, et al.

Multimodal mismatch responses in mouse auditory cortex
by: Magdalena Solyga, et al.
Published: (2025-02-01)

Adversarial subdomain adaptation network for mismatched steganalysis
by: Lei ZHANG, et al.
Published: (2022-06-01)

CORRELATION BETWEEN EFL STUDENTS’ PERCEIVED LINGUISTIC PROFICIENCY AND THEIR LEVEL OF CONFIDENCE IN USING ENGLISH
by: Mohammad Suleiman Mohammad Amro, et al.
Published: (2019-06-01)

Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer
by: Yupeng Jiang, et al.
Published: (2025-02-01)

Mucinous rectal adenocarcinoma recurrence: A case report and literature review
by: Riya Sood, BS, et al.
Published: (2025-04-01)

Design of studies on neoadjuvant therapy for intrahepatic cholangiocarcinoma
by: Yuan Cheng, et al.
Published: (2025-01-01)

Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern
by: Tuğba Günler, et al.
Published: (2024-04-01)

Evaluating the Salary Mismatch Among Secondary School Teachears in Rubanda District.
by: Atukwase, Brian
Published: (2024)