Chemokines simultaneously bind SARS-CoV-2 nucleocapsid protein RNA-binding and dimerization domains

Abstract Viruses express chemokine (CHK)-binding proteins to interfere with the host CHK network and thereby modulate leukocyte migration. SARS-CoV-2 Nucleocapsid (N) protein binds a subset of human CHKs with high affinity, inhibiting their chemoattractant properties. Here, we report that both N’s R...

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Bibliographic Details
Main Authors: Alberto Domingo López-Muñoz, Jonathan W. Yewdell
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Virology Journal
Online Access:https://doi.org/10.1186/s12985-025-02658-1
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