Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer’s disease

Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer’s disease

Abstract Synaptic loss strongly correlates with cognitive impairment in Alzheimer’s disease (AD), yet the mechanism linking its origin and pattern remain unclear. Given that connected brain regions share molecular and synaptic features, and pathological tau, a key driver of synaptic degeneration, pr...

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Main Authors: Ying Luan, Weiyi Wang, Qi Huang, Yan Wang, Jana Nussbaumer, Jie Wang, Anna Steward, Sebastian N. Roemer-Cassiano, Yihui Guan, Michael Ewers, Michael Schöll, Ruiqing Ni, Binyin Li, Nicolai Franzmeier, Fang Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61497-4
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