Human platelet lysate combined with mesenchymal stem cells pretreated with platelet lysate improved cardiac function in rats with myocardial infarction

Human platelet lysate combined with mesenchymal stem cells pretreated with platelet lysate improved cardiac function in rats with myocardial infarction

Abstract Myocardial infarction (MI) is a leading cause of heart failure, disability and mortality worldwide. In this study, the effects of intramyocardial injection of human platelet lysate (HPL), bone marrow mesenchymal stem cells pretreated with HPL (PMSCs), and PMSC lysate (lys), alone and in com...

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Main Authors: Hamid Najafipour, Farzaneh Rostamzadeh, Seedieh Jafarinejad-Farsangi, Zahra Bagheri-Hosseinabadi, Elham Jafari, Alireza Farsinejad, Mohmmad Mehdi Bagheri
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Stem cell
Platelet lysate
Myocardial infarction
Angiogenesis
Myogenesis
Online Access:https://doi.org/10.1038/s41598-024-79050-6
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