Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study
Abstract Background Lymph node dissection is a standardized procedure in gastric cancer surgery. Typically, lymph node metastasis begins in the perigastric (PG) region and then extends to the extraperigastric (EP) region. However, in some circumstances, skip lymph node metastasis occurs in the EP re...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03951-7 |
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| author | Kuang-Hua Lo Kuo-Hung Huang Wen-Liang Fang Shih-Chieh Lin Yi-Ping Hung Ming-Huang Chen Chew-Wen Wu Ching-Yun Kung |
| author_facet | Kuang-Hua Lo Kuo-Hung Huang Wen-Liang Fang Shih-Chieh Lin Yi-Ping Hung Ming-Huang Chen Chew-Wen Wu Ching-Yun Kung |
| author_sort | Kuang-Hua Lo |
| collection | DOAJ |
| description | Abstract Background Lymph node dissection is a standardized procedure in gastric cancer surgery. Typically, lymph node metastasis begins in the perigastric (PG) region and then extends to the extraperigastric (EP) region. However, in some circumstances, skip lymph node metastasis occurs in the EP region without involvement of the PG lymph nodes. This study aims to investigate the clinical significance of skip lymph node metastasis in gastric cancer. Methods A total of 1,055 patients who underwent curative gastrectomy for primary gastric cancer with pathological lymph node metastasis were analyzed. Patients were categorized into three groups: the PG-only group, the PG + EP group, and the skip group. The clinicopathologic characteristics and prognosis were analyzed. Results The incidence of skip lymph node metastasis was 3.9% (41 of 1,055 patients). The skip group had a higher proportion of females compared to both the PG-only group (43.9% vs. 27.5%, p = 0.025) and the PG + EP group (43.9% vs. 26.5%, p = 0.017). Additionally, the skip group showed a higher proportion of intestinal-type tumors compared to the PG-only group (68.3% vs. 50.6%, p = 0.029) and the PG + EP group (68.3% vs. 40.2%, p = 0.001). Disease-free survival and overall survival in the skip group were similar to those in the PG-only group but significantly better than those in the PG + EP group. Conclusions Skip lymph node metastasis is uncommon, and it is associated with a higher proportion of females and intestinal-type tumors. The prognosis of the skip group was comparable to the PG-only group and significantly better than that of the PG + EP group. |
| format | Article |
| id | doaj-art-e73386b5fc3c4d36b4d44a9eb1ca71a1 |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-e73386b5fc3c4d36b4d44a9eb1ca71a12025-08-20T03:46:09ZengBMCWorld Journal of Surgical Oncology1477-78192025-07-0123111210.1186/s12957-025-03951-7Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective studyKuang-Hua Lo0Kuo-Hung Huang1Wen-Liang Fang2Shih-Chieh Lin3Yi-Ping Hung4Ming-Huang Chen5Chew-Wen Wu6Ching-Yun Kung7Division of General Surgery, Department of Surgery, Taipei Veterans General HospitalDivision of General Surgery, Department of Surgery, Taipei Veterans General HospitalDivision of General Surgery, Department of Surgery, Taipei Veterans General HospitalSchool of Medicine, National Yang Ming Chiao Tung UniversitySchool of Medicine, National Yang Ming Chiao Tung UniversitySchool of Medicine, National Yang Ming Chiao Tung UniversityDivision of General Surgery, Department of Surgery, Taipei Veterans General HospitalDivision of General Surgery, Department of Surgery, Taipei Veterans General HospitalAbstract Background Lymph node dissection is a standardized procedure in gastric cancer surgery. Typically, lymph node metastasis begins in the perigastric (PG) region and then extends to the extraperigastric (EP) region. However, in some circumstances, skip lymph node metastasis occurs in the EP region without involvement of the PG lymph nodes. This study aims to investigate the clinical significance of skip lymph node metastasis in gastric cancer. Methods A total of 1,055 patients who underwent curative gastrectomy for primary gastric cancer with pathological lymph node metastasis were analyzed. Patients were categorized into three groups: the PG-only group, the PG + EP group, and the skip group. The clinicopathologic characteristics and prognosis were analyzed. Results The incidence of skip lymph node metastasis was 3.9% (41 of 1,055 patients). The skip group had a higher proportion of females compared to both the PG-only group (43.9% vs. 27.5%, p = 0.025) and the PG + EP group (43.9% vs. 26.5%, p = 0.017). Additionally, the skip group showed a higher proportion of intestinal-type tumors compared to the PG-only group (68.3% vs. 50.6%, p = 0.029) and the PG + EP group (68.3% vs. 40.2%, p = 0.001). Disease-free survival and overall survival in the skip group were similar to those in the PG-only group but significantly better than those in the PG + EP group. Conclusions Skip lymph node metastasis is uncommon, and it is associated with a higher proportion of females and intestinal-type tumors. The prognosis of the skip group was comparable to the PG-only group and significantly better than that of the PG + EP group.https://doi.org/10.1186/s12957-025-03951-7Gastric cancerSkip metastasisLymph node metastasis |
| spellingShingle | Kuang-Hua Lo Kuo-Hung Huang Wen-Liang Fang Shih-Chieh Lin Yi-Ping Hung Ming-Huang Chen Chew-Wen Wu Ching-Yun Kung Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study World Journal of Surgical Oncology Gastric cancer Skip metastasis Lymph node metastasis |
| title | Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study |
| title_full | Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study |
| title_fullStr | Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study |
| title_full_unstemmed | Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study |
| title_short | Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study |
| title_sort | characteristics and prognosis of skip lymph node metastasis in gastric cancer a retrospective study |
| topic | Gastric cancer Skip metastasis Lymph node metastasis |
| url | https://doi.org/10.1186/s12957-025-03951-7 |
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