Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice
Sleep bruxism is an involuntary, exaggerated jaw-closing activity during sleep. Selective serotonin reuptake inhibitor (SSRI) use is a risk factor for bruxism. However, the effect of various SSRIs on masseter (jaw-closing) muscle activity remains unclear. Here, we examined the effects of long-term a...
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Elsevier
2025-01-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010224001196 |
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| author | Minako Ikeda Ayako Mochizuki Takafumi Kato Shiro Nakamura Kiyomi Nakayama Masanori Dantsuji Kazuyoshi Baba Tomio Inoue |
| author_facet | Minako Ikeda Ayako Mochizuki Takafumi Kato Shiro Nakamura Kiyomi Nakayama Masanori Dantsuji Kazuyoshi Baba Tomio Inoue |
| author_sort | Minako Ikeda |
| collection | DOAJ |
| description | Sleep bruxism is an involuntary, exaggerated jaw-closing activity during sleep. Selective serotonin reuptake inhibitor (SSRI) use is a risk factor for bruxism. However, the effect of various SSRIs on masseter (jaw-closing) muscle activity remains unclear. Here, we examined the effects of long-term administration of two SSRIs, fluoxetine (FLX) and paroxetine (PRX), for 14 days on masseter muscle activity during wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep for 24 h in mice. Vigilance states were scored based on electroencephalographic, electrooculography and neck electromyographic (EMG) activities. The EMG activity of the masseter muscle was quantified in 6 h periods. FLX and PRX did not affect the duration of the three vigilance states. Both drugs significantly prolonged the REM sleep episode duration while decreasing the number of episodes. FLX significantly increased REM sleep onset latency. Neither FLX nor PRX affected the mean masseter EMG activity during wakefulness. FLX significantly increased the relative time of masseter muscle activity in NREM sleep during 02:00–08:00 and 08:00–14:00, while PRX did not affect three vigilance states. Overall, FLX had a limited but significant effect on masseter muscle activity in NREM sleep during specific periods. |
| format | Article |
| id | doaj-art-e70c6ed52aa84a3ea45dfa4bbae7be16 |
| institution | Kabale University |
| issn | 0168-0102 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Neuroscience Research |
| spelling | doaj-art-e70c6ed52aa84a3ea45dfa4bbae7be162025-01-16T04:28:17ZengElsevierNeuroscience Research0168-01022025-01-012105161Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in miceMinako Ikeda0Ayako Mochizuki1Takafumi Kato2Shiro Nakamura3Kiyomi Nakayama4Masanori Dantsuji5Kazuyoshi Baba6Tomio Inoue7Department of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; Department of Prosthodontics, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, JapanDepartment of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; Corresponding author.Department of Oral Physiology, Osaka University Graduation School of Density, 1-8, Yamadaoka, Suita, Osaka 565-0871, Japan; Sleep Medicine Center, Osaka University Hospital, 1-8, Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, JapanDepartment of Prosthodontics, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, JapanDepartment of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; Department of Contemporary Life Design, Kyoto Koka Women's College, 38 Nishikyogoku Kadono-cho, Ukyo-ku, Kyoto, JapanSleep bruxism is an involuntary, exaggerated jaw-closing activity during sleep. Selective serotonin reuptake inhibitor (SSRI) use is a risk factor for bruxism. However, the effect of various SSRIs on masseter (jaw-closing) muscle activity remains unclear. Here, we examined the effects of long-term administration of two SSRIs, fluoxetine (FLX) and paroxetine (PRX), for 14 days on masseter muscle activity during wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep for 24 h in mice. Vigilance states were scored based on electroencephalographic, electrooculography and neck electromyographic (EMG) activities. The EMG activity of the masseter muscle was quantified in 6 h periods. FLX and PRX did not affect the duration of the three vigilance states. Both drugs significantly prolonged the REM sleep episode duration while decreasing the number of episodes. FLX significantly increased REM sleep onset latency. Neither FLX nor PRX affected the mean masseter EMG activity during wakefulness. FLX significantly increased the relative time of masseter muscle activity in NREM sleep during 02:00–08:00 and 08:00–14:00, while PRX did not affect three vigilance states. Overall, FLX had a limited but significant effect on masseter muscle activity in NREM sleep during specific periods.http://www.sciencedirect.com/science/article/pii/S0168010224001196Serotonin reuptake inhibitorFluoxetineParoxetineNon-rapid eye movement (NREM) sleepRapid eye movement (REM) sleepElectroencephalography |
| spellingShingle | Minako Ikeda Ayako Mochizuki Takafumi Kato Shiro Nakamura Kiyomi Nakayama Masanori Dantsuji Kazuyoshi Baba Tomio Inoue Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice Neuroscience Research Serotonin reuptake inhibitor Fluoxetine Paroxetine Non-rapid eye movement (NREM) sleep Rapid eye movement (REM) sleep Electroencephalography |
| title | Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice |
| title_full | Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice |
| title_fullStr | Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice |
| title_full_unstemmed | Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice |
| title_short | Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice |
| title_sort | fluoxetine but not paroxetine alters the jaw closing muscle activity during non rapid eye movement sleep in mice |
| topic | Serotonin reuptake inhibitor Fluoxetine Paroxetine Non-rapid eye movement (NREM) sleep Rapid eye movement (REM) sleep Electroencephalography |
| url | http://www.sciencedirect.com/science/article/pii/S0168010224001196 |
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