Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate muscle atrophy via the miR-132-3p/FoxO3 axis

Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate muscle atrophy via the miR-132-3p/FoxO3 axis

Background: Muscle atrophy or sarcopenia is the loss of muscle mass and strength and leads to an increased risk of disability and death including osteoporotic fractures. Currently, there are no available clinical biologic agents for the treatment of sarcopenia. Since exosomes have become increasingl...

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Bibliographic Details
Main Authors: Huihui Ma, Yujie Jing, Jiangping Zeng, Jiaying Ge, Siqi Sun, Ran Cui, Chunhua Qian, Shen Qu, Hui Sheng
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Orthopaedic Translation
Subjects:
Exosomes
FoxO3
Human umbilical cord mesenchymal stem cells
Muscle atrophy
MiR-132-3p
Sarcopenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24000925
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