Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma
Abstract Uterine corpus endometrial carcinoma (UCEC) is a significant cause of cancer-related mortality among women worldwide. Prior research has demonstrated an association between cyclin-dependent kinase inhibitor 2 A (CDKN2A) and various tumors. As a member of the INK4 family, CDKN2A is involved...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-85364-w |
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| author | Liang Ma Yuling Li Jingxian Wu Yanfei Gao |
| author_facet | Liang Ma Yuling Li Jingxian Wu Yanfei Gao |
| author_sort | Liang Ma |
| collection | DOAJ |
| description | Abstract Uterine corpus endometrial carcinoma (UCEC) is a significant cause of cancer-related mortality among women worldwide. Prior research has demonstrated an association between cyclin-dependent kinase inhibitor 2 A (CDKN2A) and various tumors. As a member of the INK4 family, CDKN2A is involved in cell cycle regulation by controlling CDKs. In the present study, bioinformatics was used to analyze public datasets. The expression levels, signaling pathways, and copy number variations of CDKN2A in UCEC were explored, along with its immune cell subset associations. CDKN2A expression was found to be elevated in UCEC, particularly in the signaling pathways involved in cell proliferation and inflammation. Analysis of somatic copy number alterations in the TCGA (The Cancer Genome Atlas)-UCEC dataset revealed a connection between CDKN2A and drug metabolism in UCEC. Assessment of the relationship between CDKN2A and genes involved in immunotherapy for UCEC patients showed a negative correlation between CDKN2A and CD8+ T cell activity, as well as IL-2 and TP53. Collectively, these insights suggest that CDKN2A may be a potential biomarker for prognosis and treatment strategies in UCEC. |
| format | Article |
| id | doaj-art-e70427d4c7f74c91b478f451b3d2fbb3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e70427d4c7f74c91b478f451b3d2fbb32025-01-12T12:22:05ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-85364-wBioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinomaLiang Ma0Yuling Li1Jingxian Wu2Yanfei Gao3Department of Pathology, College of Basic Medicine, Chongqing Medical UniversityBiochemistry and Molecular Biology, College of Basic Medical Science, Chongqing Medical UniversityDepartment of Pathology, College of Basic Medicine, Chongqing Medical UniversityBiochemistry and Molecular Biology, College of Basic Medical Science, Chongqing Medical UniversityAbstract Uterine corpus endometrial carcinoma (UCEC) is a significant cause of cancer-related mortality among women worldwide. Prior research has demonstrated an association between cyclin-dependent kinase inhibitor 2 A (CDKN2A) and various tumors. As a member of the INK4 family, CDKN2A is involved in cell cycle regulation by controlling CDKs. In the present study, bioinformatics was used to analyze public datasets. The expression levels, signaling pathways, and copy number variations of CDKN2A in UCEC were explored, along with its immune cell subset associations. CDKN2A expression was found to be elevated in UCEC, particularly in the signaling pathways involved in cell proliferation and inflammation. Analysis of somatic copy number alterations in the TCGA (The Cancer Genome Atlas)-UCEC dataset revealed a connection between CDKN2A and drug metabolism in UCEC. Assessment of the relationship between CDKN2A and genes involved in immunotherapy for UCEC patients showed a negative correlation between CDKN2A and CD8+ T cell activity, as well as IL-2 and TP53. Collectively, these insights suggest that CDKN2A may be a potential biomarker for prognosis and treatment strategies in UCEC.https://doi.org/10.1038/s41598-025-85364-wCDKN2AUterine corpus endometrial carcinomaCDKN2A expressionSomatic copy number alteration analysisImmunotherapy |
| spellingShingle | Liang Ma Yuling Li Jingxian Wu Yanfei Gao Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma Scientific Reports CDKN2A Uterine corpus endometrial carcinoma CDKN2A expression Somatic copy number alteration analysis Immunotherapy |
| title | Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma |
| title_full | Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma |
| title_fullStr | Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma |
| title_full_unstemmed | Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma |
| title_short | Bioinformatics approaches to multi-omics analysis of the potential of CDKN2A as a biomarker and therapeutic target for uterine corpus endometrial carcinoma |
| title_sort | bioinformatics approaches to multi omics analysis of the potential of cdkn2a as a biomarker and therapeutic target for uterine corpus endometrial carcinoma |
| topic | CDKN2A Uterine corpus endometrial carcinoma CDKN2A expression Somatic copy number alteration analysis Immunotherapy |
| url | https://doi.org/10.1038/s41598-025-85364-w |
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